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Antemortem Diagnosis of New York Human Rabies Case and Review of U.S. Cases
To help elucidate rabies disease patterns and control issues, a full assessment of a human case of dog-variant rabies was undertaken. In 2000, a 54-year-old man presented to a New York hospital with lower back discomfort four days after arrival from Africa. Rabies was first suspected 8 days after ho...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Master Publishing Group
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614649/ https://www.ncbi.nlm.nih.gov/pubmed/23675013 |
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author | Soun, Vince V. Eidson, Millicent Wallace, Barbara J. Drabkin, Peter D. Jones, Ginelle Leach, Richard Cantiello, Kathy Trimarchi, Charles V. Qian, Jiang |
author_facet | Soun, Vince V. Eidson, Millicent Wallace, Barbara J. Drabkin, Peter D. Jones, Ginelle Leach, Richard Cantiello, Kathy Trimarchi, Charles V. Qian, Jiang |
author_sort | Soun, Vince V. |
collection | PubMed |
description | To help elucidate rabies disease patterns and control issues, a full assessment of a human case of dog-variant rabies was undertaken. In 2000, a 54-year-old man presented to a New York hospital with lower back discomfort four days after arrival from Africa. Rabies was first suspected 8 days after hospitalization based on clinical signs, specimens were collected on the same day, and rabies infection was confirmed the following day (fluorescence antibody testing on nuchal skin biopsy specimen). By the 12(th) day after illness onset, he was unresponsive, and life support was removed on day 15. Subsequently, an African dog variant was confirmed by nucleic acid sequence analysis of rabies viral RNA extracted and amplified from the patient’s saliva. Management of human concerns about exposure to the patient kept the number of persons receiving postexposure prophylaxis to 26. With less than half of the U.S. human rabies cases being diagnosed antemortem, this case emphasizes the need to routinely include rabies in the differential diagnosis of any unexplained encephalitis to ensure early confirmation and triage of human contacts to reduce associated healthcare costs. |
format | Online Article Text |
id | pubmed-3614649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Master Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36146492013-05-01 Antemortem Diagnosis of New York Human Rabies Case and Review of U.S. Cases Soun, Vince V. Eidson, Millicent Wallace, Barbara J. Drabkin, Peter D. Jones, Ginelle Leach, Richard Cantiello, Kathy Trimarchi, Charles V. Qian, Jiang Int J Biomed Sci Case Report To help elucidate rabies disease patterns and control issues, a full assessment of a human case of dog-variant rabies was undertaken. In 2000, a 54-year-old man presented to a New York hospital with lower back discomfort four days after arrival from Africa. Rabies was first suspected 8 days after hospitalization based on clinical signs, specimens were collected on the same day, and rabies infection was confirmed the following day (fluorescence antibody testing on nuchal skin biopsy specimen). By the 12(th) day after illness onset, he was unresponsive, and life support was removed on day 15. Subsequently, an African dog variant was confirmed by nucleic acid sequence analysis of rabies viral RNA extracted and amplified from the patient’s saliva. Management of human concerns about exposure to the patient kept the number of persons receiving postexposure prophylaxis to 26. With less than half of the U.S. human rabies cases being diagnosed antemortem, this case emphasizes the need to routinely include rabies in the differential diagnosis of any unexplained encephalitis to ensure early confirmation and triage of human contacts to reduce associated healthcare costs. Master Publishing Group 2006-12 /pmc/articles/PMC3614649/ /pubmed/23675013 Text en © Vince V. Soun et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Soun, Vince V. Eidson, Millicent Wallace, Barbara J. Drabkin, Peter D. Jones, Ginelle Leach, Richard Cantiello, Kathy Trimarchi, Charles V. Qian, Jiang Antemortem Diagnosis of New York Human Rabies Case and Review of U.S. Cases |
title | Antemortem Diagnosis of New York Human Rabies Case and Review of U.S. Cases |
title_full | Antemortem Diagnosis of New York Human Rabies Case and Review of U.S. Cases |
title_fullStr | Antemortem Diagnosis of New York Human Rabies Case and Review of U.S. Cases |
title_full_unstemmed | Antemortem Diagnosis of New York Human Rabies Case and Review of U.S. Cases |
title_short | Antemortem Diagnosis of New York Human Rabies Case and Review of U.S. Cases |
title_sort | antemortem diagnosis of new york human rabies case and review of u.s. cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614649/ https://www.ncbi.nlm.nih.gov/pubmed/23675013 |
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