An Investigation on the Solid Dispersions of Chlordiazepoxide

The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid dispersions of chlordiazepoxide in polyvinylpyrrolidone (PVP), Eudragit E100, Mannitol and Sorbitol with two different ratios of drug to carrier (5:5 and 1:9) were prepared. These solid dispersions were evaluated using dissolution tester to monitor dissolution behaviour and Fourier-transform infrared spectroscopy to investigate interaction between the drug and carriers in solid dispersion samples. Solid dispersion of chlordiazepoxide with all three carriers (PVP, mannitol and eudragit E) prepared by solvent method showed considerable increase in the dissolution rate of chlordiazepoxide in comparison with physical mixture and pure drug at different pH values. According to the results of this investigation cogrinding technique yields solid dispersions with a less improved dissolution rate than does the solvent deposition technique. Infrared studies showed no interaction between chlordiazepoxide and carriers in solid dispersions in solid state.