Overcoming Hurdles in Hepatitis C Virus Research: Efficient Production of Infectious Virus in Cell Culture

Hepatitis C virus is a flavivirus that infects nearly 2% of the world population. There is no vaccine available and current therapy with interferon and ribavirin is expensive, not well tolerated and effective in only 60% of patients. HCV research has been hampered by the lack of a robust tissue cult...

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Detalles Bibliográficos
Autores principales: Silberstein, Erica, Taylor, Deborah R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614688/
https://www.ncbi.nlm.nih.gov/pubmed/23675072
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author Silberstein, Erica
Taylor, Deborah R.
author_facet Silberstein, Erica
Taylor, Deborah R.
author_sort Silberstein, Erica
collection PubMed
description Hepatitis C virus is a flavivirus that infects nearly 2% of the world population. There is no vaccine available and current therapy with interferon and ribavirin is expensive, not well tolerated and effective in only 60% of patients. HCV research has been hampered by the lack of a robust tissue culture system, but recent advances have made virus growth in culture possible. Here we review the current state-of-the-art and the molecular hurdles that have been met and those that still need to be overcome.
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spelling pubmed-36146882013-05-01 Overcoming Hurdles in Hepatitis C Virus Research: Efficient Production of Infectious Virus in Cell Culture Silberstein, Erica Taylor, Deborah R. Int J Biomed Sci Article Hepatitis C virus is a flavivirus that infects nearly 2% of the world population. There is no vaccine available and current therapy with interferon and ribavirin is expensive, not well tolerated and effective in only 60% of patients. HCV research has been hampered by the lack of a robust tissue culture system, but recent advances have made virus growth in culture possible. Here we review the current state-of-the-art and the molecular hurdles that have been met and those that still need to be overcome. Master Publishing Group 2008-06 /pmc/articles/PMC3614688/ /pubmed/23675072 Text en © Erica Silberstein et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Silberstein, Erica
Taylor, Deborah R.
Overcoming Hurdles in Hepatitis C Virus Research: Efficient Production of Infectious Virus in Cell Culture
title Overcoming Hurdles in Hepatitis C Virus Research: Efficient Production of Infectious Virus in Cell Culture
title_full Overcoming Hurdles in Hepatitis C Virus Research: Efficient Production of Infectious Virus in Cell Culture
title_fullStr Overcoming Hurdles in Hepatitis C Virus Research: Efficient Production of Infectious Virus in Cell Culture
title_full_unstemmed Overcoming Hurdles in Hepatitis C Virus Research: Efficient Production of Infectious Virus in Cell Culture
title_short Overcoming Hurdles in Hepatitis C Virus Research: Efficient Production of Infectious Virus in Cell Culture
title_sort overcoming hurdles in hepatitis c virus research: efficient production of infectious virus in cell culture
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614688/
https://www.ncbi.nlm.nih.gov/pubmed/23675072
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