Cargando…

Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients?

It is well established that there is a high incidence of cardiovascular diseases in hemodialysis patients, and involvement of oxidative stress has been hypothesised in these phenomena. Plasma norepinephrine is an independent predictor of many causes of mortality in general, and high norepinephrine l...

Descripción completa

Detalles Bibliográficos
Autores principales: Coquet, Isaline, Doise, Jean-Marc, Guilland, Jean-Claude, Vergely, Catherine, Mousson, Christiane, Rochette, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614698/
https://www.ncbi.nlm.nih.gov/pubmed/23675078
_version_ 1782264895726682112
author Coquet, Isaline
Doise, Jean-Marc
Guilland, Jean-Claude
Vergely, Catherine
Mousson, Christiane
Rochette, Luc
author_facet Coquet, Isaline
Doise, Jean-Marc
Guilland, Jean-Claude
Vergely, Catherine
Mousson, Christiane
Rochette, Luc
author_sort Coquet, Isaline
collection PubMed
description It is well established that there is a high incidence of cardiovascular diseases in hemodialysis patients, and involvement of oxidative stress has been hypothesised in these phenomena. Plasma norepinephrine is an independent predictor of many causes of mortality in general, and high norepinephrine levels predict cardiovascular complications in end stage renal disease. The aim of our study was to evaluate the potential link between vitamin C status, a marker of oxidative stress, and catecholamine concentrations before and after hemodialysis sessions. In a prospective study of 16 chronic hemodialysis patients, ascorbyl free radical levels were directly measured using electron spin resonance spectroscopy. These values were expressed with respect to vitamin C concentrations to obtain a direct index of oxidative stress. Vitamin C, epinephrine and norepinephrine were measured by high performance liquid chromatography. The data were examined for correlations between these compounds and clinical parameters including blood pressure and heart rates. In hemodialysis patients, ascorbyl free radical/vitamin C ratios increased significantly after dialysis. No differences were observed for catecholamine concentrations during hemodialysis sessions. In multivariate analysis, the ascorbyl free radical/vitamin C ratio did not correlate with epinephrine or norepinephrine levels. In our study, plasma norepinephrine and ascorbyl free radical/vitamin C ratios were not related among patients with end-stage renal disease. From these findings, we conclude that although these two factors are likely to be involved in the same causal pathway leading to cardiovascular events, it is likely that they seem to be independent.
format Online
Article
Text
id pubmed-3614698
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Master Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-36146982013-05-01 Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients? Coquet, Isaline Doise, Jean-Marc Guilland, Jean-Claude Vergely, Catherine Mousson, Christiane Rochette, Luc Int J Biomed Sci Article It is well established that there is a high incidence of cardiovascular diseases in hemodialysis patients, and involvement of oxidative stress has been hypothesised in these phenomena. Plasma norepinephrine is an independent predictor of many causes of mortality in general, and high norepinephrine levels predict cardiovascular complications in end stage renal disease. The aim of our study was to evaluate the potential link between vitamin C status, a marker of oxidative stress, and catecholamine concentrations before and after hemodialysis sessions. In a prospective study of 16 chronic hemodialysis patients, ascorbyl free radical levels were directly measured using electron spin resonance spectroscopy. These values were expressed with respect to vitamin C concentrations to obtain a direct index of oxidative stress. Vitamin C, epinephrine and norepinephrine were measured by high performance liquid chromatography. The data were examined for correlations between these compounds and clinical parameters including blood pressure and heart rates. In hemodialysis patients, ascorbyl free radical/vitamin C ratios increased significantly after dialysis. No differences were observed for catecholamine concentrations during hemodialysis sessions. In multivariate analysis, the ascorbyl free radical/vitamin C ratio did not correlate with epinephrine or norepinephrine levels. In our study, plasma norepinephrine and ascorbyl free radical/vitamin C ratios were not related among patients with end-stage renal disease. From these findings, we conclude that although these two factors are likely to be involved in the same causal pathway leading to cardiovascular events, it is likely that they seem to be independent. Master Publishing Group 2008-06 /pmc/articles/PMC3614698/ /pubmed/23675078 Text en © Isaline Coquet et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Coquet, Isaline
Doise, Jean-Marc
Guilland, Jean-Claude
Vergely, Catherine
Mousson, Christiane
Rochette, Luc
Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients?
title Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients?
title_full Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients?
title_fullStr Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients?
title_full_unstemmed Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients?
title_short Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients?
title_sort is there a correlation between vitamin c status and catecholamines concentrations in hemodialysis patients?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614698/
https://www.ncbi.nlm.nih.gov/pubmed/23675078
work_keys_str_mv AT coquetisaline isthereacorrelationbetweenvitamincstatusandcatecholaminesconcentrationsinhemodialysispatients
AT doisejeanmarc isthereacorrelationbetweenvitamincstatusandcatecholaminesconcentrationsinhemodialysispatients
AT guillandjeanclaude isthereacorrelationbetweenvitamincstatusandcatecholaminesconcentrationsinhemodialysispatients
AT vergelycatherine isthereacorrelationbetweenvitamincstatusandcatecholaminesconcentrationsinhemodialysispatients
AT moussonchristiane isthereacorrelationbetweenvitamincstatusandcatecholaminesconcentrationsinhemodialysispatients
AT rochetteluc isthereacorrelationbetweenvitamincstatusandcatecholaminesconcentrationsinhemodialysispatients