Non-Markovian Population Dynamics: Does it Help to Optimize the Chemotherapeutic Strategy?

A non-Markovian theory of population dynamics is to simulate the anti-cancer drug distribution between malignant and the hosting normal cell pools. The model takes into account both the cell life span and the proliferation rate differences. This new simulation approach looks promising for its potent...

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Detalles Bibliográficos
Autores principales: Kuznetsov, Dmitry A., Roumiantsev, Sergey A., Fallahi, Majid, Amirshahi, Nima, Makarov, Andrey V., Kardashova, Karina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614726/
https://www.ncbi.nlm.nih.gov/pubmed/23675179
Descripción
Sumario:A non-Markovian theory of population dynamics is to simulate the anti-cancer drug distribution between malignant and the hosting normal cell pools. The model takes into account both the cell life span and the proliferation rate differences. This new simulation approach looks promising for its potential to optimize a chemotherapeutic strategy by choosing the scheme with a higher degree of the drug-tumor selectivity. The pre-test designed simulation mode fits nicely the experimental data on Porphylleren-MC16 (PMC16) pharmacokinetics patterns including the allometric plots revealed for this novel medicinal nanoparticle possessing some anti-cancer potential and intervening into the oxygen-independent ATP production mechanisms.

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