Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents

The synthesis of hydroxy benzophenones and benzophenone-N-ethyl morpholine ethers and the results of anti-inflammatory activity in vivo are described. The structures of the compounds were elucidated by IR, (1)H-NMR, mass spectroscopy and the elementary analysis. The anti-inflammatory activity of the...

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Autores principales: Khanum, Shaukath A., Begum, Bushra A., Girish, V., Khanum, Noor Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614727/
https://www.ncbi.nlm.nih.gov/pubmed/23675177
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author Khanum, Shaukath A.
Begum, Bushra A.
Girish, V.
Khanum, Noor Fatima
author_facet Khanum, Shaukath A.
Begum, Bushra A.
Girish, V.
Khanum, Noor Fatima
author_sort Khanum, Shaukath A.
collection PubMed
description The synthesis of hydroxy benzophenones and benzophenone-N-ethyl morpholine ethers and the results of anti-inflammatory activity in vivo are described. The structures of the compounds were elucidated by IR, (1)H-NMR, mass spectroscopy and the elementary analysis. The anti-inflammatory activity of the synthesized compounds were determined by carrageenan-induced hind paw oedema test in rats. Most of the tested compounds exhibited anti-inflammatory activity and some of them were more active than standard drugs. In addition ulcerogenic and cyclooxygenase activities are also described.
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spelling pubmed-36147272013-05-01 Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents Khanum, Shaukath A. Begum, Bushra A. Girish, V. Khanum, Noor Fatima Int J Biomed Sci Original Article The synthesis of hydroxy benzophenones and benzophenone-N-ethyl morpholine ethers and the results of anti-inflammatory activity in vivo are described. The structures of the compounds were elucidated by IR, (1)H-NMR, mass spectroscopy and the elementary analysis. The anti-inflammatory activity of the synthesized compounds were determined by carrageenan-induced hind paw oedema test in rats. Most of the tested compounds exhibited anti-inflammatory activity and some of them were more active than standard drugs. In addition ulcerogenic and cyclooxygenase activities are also described. Master Publishing Group 2010-03 /pmc/articles/PMC3614727/ /pubmed/23675177 Text en © Shaukath A. Khanum et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Khanum, Shaukath A.
Begum, Bushra A.
Girish, V.
Khanum, Noor Fatima
Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents
title Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents
title_full Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents
title_fullStr Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents
title_full_unstemmed Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents
title_short Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents
title_sort synthesis and evaluation of benzophenone-n-ethyl morpholine ethers as anti-inflammatory agents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614727/
https://www.ncbi.nlm.nih.gov/pubmed/23675177
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