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Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats
The aim of the study was to explore the effect of Gynostemma pentaphyllum (GP) extract on hepatic glucose output (HGO) in spontaneously type 2 diabetic Goto-Kakizaki (GK) rats treated orally with GP or placebo extract 1600 mg/kg daily, during three days or three weeks. The three-week treatment of GP...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Master Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614830/ https://www.ncbi.nlm.nih.gov/pubmed/23675229 |
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author | Yassin, K. Huyen, V. T. T. Hoa, K. N. Östenson, C. G. |
author_facet | Yassin, K. Huyen, V. T. T. Hoa, K. N. Östenson, C. G. |
author_sort | Yassin, K. |
collection | PubMed |
description | The aim of the study was to explore the effect of Gynostemma pentaphyllum (GP) extract on hepatic glucose output (HGO) in spontaneously type 2 diabetic Goto-Kakizaki (GK) rats treated orally with GP or placebo extract 1600 mg/kg daily, during three days or three weeks. The three-week treatment of GP, but not three-day treatment, significantly reduced plasma glucose (PG) levels from 9.8 ± 0.6 to 6.8 ± 0.4 mmol/L (p=0.027) in GK rats, whereas PG levels were not significantly decreased in the placebo rats. Glucose tolerance assessed by an intra-peritoneal glucose tolerance test was significantly improved in GP treated compared to placebo treated group (areas under the glucose curves, AUCs, from 0 to 120 min were 1150 ± 200 vs. 1761 ± 87 mmol/L; p=0.013). The glucose response in an intra-peritoneal pyruvate tolerance test from minute 15 to minute 120, the AUC (15-120) was significantly lower in the GP group (415.5 ± 68.0 vs. 641.5 ± 41.8 mmol/L; p<0.05). In liver perfusions, the AUCs for HGO during 18 min (0-18 min) were significantly decreased in GP treated rats compared with control rats (302.8 ± 36.5 vs. 423.5 ± 44.7 μmol, p<0.05). The three-week GP treatment significantly reduced the hepatic glycogen content, but not glycogen synthase activity compared to placebo group (p<0.007). In conclusion, three-week treatment of GP extract exerted anti-diabetic effect in GK rats, reducing plasma glucose levels and HGO, suggesting that GP improves the hepatic insulin sensitivity by suppressing gluconeogenesis. |
format | Online Article Text |
id | pubmed-3614830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Master Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36148302013-05-01 Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats Yassin, K. Huyen, V. T. T. Hoa, K. N. Östenson, C. G. Int J Biomed Sci Article The aim of the study was to explore the effect of Gynostemma pentaphyllum (GP) extract on hepatic glucose output (HGO) in spontaneously type 2 diabetic Goto-Kakizaki (GK) rats treated orally with GP or placebo extract 1600 mg/kg daily, during three days or three weeks. The three-week treatment of GP, but not three-day treatment, significantly reduced plasma glucose (PG) levels from 9.8 ± 0.6 to 6.8 ± 0.4 mmol/L (p=0.027) in GK rats, whereas PG levels were not significantly decreased in the placebo rats. Glucose tolerance assessed by an intra-peritoneal glucose tolerance test was significantly improved in GP treated compared to placebo treated group (areas under the glucose curves, AUCs, from 0 to 120 min were 1150 ± 200 vs. 1761 ± 87 mmol/L; p=0.013). The glucose response in an intra-peritoneal pyruvate tolerance test from minute 15 to minute 120, the AUC (15-120) was significantly lower in the GP group (415.5 ± 68.0 vs. 641.5 ± 41.8 mmol/L; p<0.05). In liver perfusions, the AUCs for HGO during 18 min (0-18 min) were significantly decreased in GP treated rats compared with control rats (302.8 ± 36.5 vs. 423.5 ± 44.7 μmol, p<0.05). The three-week GP treatment significantly reduced the hepatic glycogen content, but not glycogen synthase activity compared to placebo group (p<0.007). In conclusion, three-week treatment of GP extract exerted anti-diabetic effect in GK rats, reducing plasma glucose levels and HGO, suggesting that GP improves the hepatic insulin sensitivity by suppressing gluconeogenesis. Master Publishing Group 2011-06 /pmc/articles/PMC3614830/ /pubmed/23675229 Text en © K. Yassin et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Yassin, K. Huyen, V. T. T. Hoa, K. N. Östenson, C. G. Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats |
title | Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats |
title_full | Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats |
title_fullStr | Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats |
title_full_unstemmed | Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats |
title_short | Herbal Extract of Gynostemma Pentaphyllum Decreases Hepatic Glucose Output in Type 2 Diabetic Goto-Kakizaki Rats |
title_sort | herbal extract of gynostemma pentaphyllum decreases hepatic glucose output in type 2 diabetic goto-kakizaki rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614830/ https://www.ncbi.nlm.nih.gov/pubmed/23675229 |
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