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A Pareto-Optimal Refinement Method for Protein Design Scaffolds
Computational design of protein function involves a search for amino acids with the lowest energy subject to a set of constraints specifying function. In many cases a set of natural protein backbone structures, or “scaffolds”, are searched to find regions where functional sites (an enzyme active sit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614904/ https://www.ncbi.nlm.nih.gov/pubmed/23565140 http://dx.doi.org/10.1371/journal.pone.0059004 |