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A Pareto-Optimal Refinement Method for Protein Design Scaffolds

Computational design of protein function involves a search for amino acids with the lowest energy subject to a set of constraints specifying function. In many cases a set of natural protein backbone structures, or “scaffolds”, are searched to find regions where functional sites (an enzyme active sit...

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Detalles Bibliográficos
Autores principales: Nivón, Lucas Gregorio, Moretti, Rocco, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614904/
https://www.ncbi.nlm.nih.gov/pubmed/23565140
http://dx.doi.org/10.1371/journal.pone.0059004

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