Cargando…

CG0009, a Novel Glycogen Synthase Kinase 3 Inhibitor, Induces Cell Death through Cyclin D1 Depletion in Breast Cancer Cells

Glycogen synthase kinase 3α/β (GSK3α/β) is a constitutively active serine/threonine kinase involved in multiple physiological processes, such as protein synthesis, stem cell maintenance and apoptosis, and acts as a key suppressor of the Wnt-β-catenin pathway. In the present study, we examined the th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hyun Mi, Kim, Choung-Soo, Lee, Je-Hwan, Jang, Se Jin, Hwang, Jung Jin, Ro, Seonggu, Choi, Jene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614906/ https://www.ncbi.nlm.nih.gov/pubmed/23565238 http://dx.doi.org/10.1371/journal.pone.0060383

Ejemplares similares

Epigenetic Modulation with HDAC Inhibitor CG200745 Induces Anti-Proliferation in Non-Small Cell Lung Cancer Cells
por: Chun, Sung-Min, et al.
Publicado: (2015)

EHMTI-0009. A particular case of cluster headache
por: Tertan, D, et al.
Publicado: (2014)

Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis
por: Park, Hyunsoo, et al.
Publicado: (2016)

A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance
por: Lee, Hee Seung, et al.
Publicado: (2017)

Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer
por: Cho, Yu Jin, et al.
Publicado: (2010)

Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels
por: Yang, Ke, et al.
Publicado: (2006)

Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats
por: Lee, Eunjo, et al.
Publicado: (2016)

Glycogen Synthase Kinase-3
por: Crouch, Peter, et al.
Publicado: (2011)

Control of Glycogen Content in Retina: Allosteric Regulation of Glycogen Synthase
por: Osorio-Paz, Ixchel, et al.
Publicado: (2012)

Glycogen synthase kinase-3β inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth
por: Kroon, Jan, et al.
Publicado: (2013)

Influence of pressure on the transport, magnetic, and structural properties of superconducting Cr(0.0009)NbSe(2) single crystal
por: Manikandan, K., et al.
Publicado: (2020)

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
por: Moujalled, Diane, et al.
Publicado: (2013)

Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression
por: Mishra, Rajakishore, et al.
Publicado: (2015)

Regulation by Glycogen Synthase Kinase-3 of Inflammation and T Cells in CNS Diseases
por: Beurel, Eléonore
Publicado: (2011)

Mechanism of glycogen synthase inactivation and interaction with glycogenin
por: Marr, Laura, et al.
Publicado: (2022)

Interactomes of Glycogen Synthase Kinase-3 Isoforms
por: Cormier, Kevin W., et al.
Publicado: (2023)

Depletion of CG-Specific Methylation in Mycoplasma hyorhinis Genomic DNA after Host Cell Invasion
por: Chernov, Andrei V., et al.
Publicado: (2015)

Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells
por: Gao, Yuan, et al.
Publicado: (2019)

Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases
por: Pursell, Natalie, et al.
Publicado: (2018)

Regulation of Cell Survival Mechanisms in Alzheimer's Disease by Glycogen Synthase Kinase-3
por: Mines, Marjelo A., et al.
Publicado: (2011)

Pharmacological Inhibition of Glycogen Synthase Kinase 3 Regulates T Cell Development In Vitro
por: Schroeder, Jan-Hendrik, et al.
Publicado: (2013)

Deletion of Glycogen Synthase Kinase 3 Beta Reprograms NK Cell Metabolism
por: Pereira, Marcelo S. F., et al.
Publicado: (2023)

Hexokinase 2, Glycogen Synthase and Phosphorylase Play a Key Role in Muscle Glycogen Supercompensation
por: Irimia, José M., et al.
Publicado: (2012)

Glycogen synthase kinase 3β in tumorigenesis and oncotherapy
por: He, Rui, et al.
Publicado: (2020)

Regenerative potential of targeting glycogen synthase kinase-3 signaling in neural tissues
por: Jung, Eui-Man, et al.
Publicado: (2015)

Erratum. Therapeutic Inertia Is a Problem for All of Us. Clinical Diabetes 2019;37:105–106 (DOI: 10.2337/cd19-0009)
por: Brunton, Stephen A.
Publicado: (2020)

Treatment With Glycogen Synthase Kinase 3β Inhibitor Decreases Apoptotic and Autophagic Reactions in Rat Rotator Cuff Tears
por: Kim, Yang-Soo, et al.
Publicado: (2021)

Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma
por: Bilim, V, et al.
Publicado: (2009)

Correction: Pharmacological Inhibition of Glycogen Synthase Kinase 3 Regulates T Cell Development In Vitro
por: Schroeder, Jan-Hendrik, et al.
Publicado: (2013)

Polarized Regulation of Glycogen Synthase Kinase-3β Is Important for Glioma Cell Invasion
por: Zou, Qifei, et al.
Publicado: (2013)

The role of glycogen synthase kinase-3β in glioma cell apoptosis induced by remifentanil
por: Xu, Jing, et al.
Publicado: (2013)

Glycogen Synthase Kinase 3 Regulates the Genesis of Displaced Retinal Ganglion Cells3
por: Kisseleff, Elena, et al.
Publicado: (2021)

cg04448376, cg24387542, cg08548498, and cg14621323 as a Novel Signature to Predict Prognosis in Kidney Renal Papillary Cell Carcinoma
por: Wang, Ying-Lei, et al.
Publicado: (2020)

Ginsenoside Rd Attenuates Tau Phosphorylation in Olfactory Bulb, Spinal Cord, and Telencephalon by Regulating Glycogen Synthase Kinase 3β and Cyclin-Dependent Kinase 5
por: Li, Ling, et al.
Publicado: (2021)

Specific Biological Activity of Equine Chorionic Gonadotropin (eCG) Glycosylation Sites in Cells Expressing Equine Luteinizing Hormone/CG (eLH/CG) Receptor
por: Byambaragchaa, Munkhzaya, et al.
Publicado: (2021)

Role of nuclear glycogen synthase and cytoplasmic UDP glucose pyrophosphorylase in the biosynthesis of nuclear glycogen in HD33 Ehrlich-Lettre ascites tumor cells
Publicado: (1981)

Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells
por: Hur, Eun-Hye, et al.
Publicado: (2017)

Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death
por: Piazza, Francesco, et al.
Publicado: (2010)

Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells
por: Taylor, Alison, et al.
Publicado: (2020)

Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
por: Koh, Seong-Ho, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_r86h86vip4chc9tfm04g0ce2o1