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DOTA-Functionalized Polylysine: A High Number of DOTA Chelates Positively Influences the Biodistribution of Enzymatic Conjugated Anti-Tumor Antibody chCE7agl

Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio. In the present study, we have investigated the influence of different numbers of 1,4,7,10-tetraazacyclododecane-N-N′-N′′-N′′′-tetraacetic...

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Detalles Bibliográficos
Autores principales:	Grünberg, Jürgen, Jeger, Simone, Sarko, Dikran, Dennler, Patrick, Zimmermann, Kurt, Mier, Walter, Schibli, Roger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614955/ https://www.ncbi.nlm.nih.gov/pubmed/23565233 http://dx.doi.org/10.1371/journal.pone.0060350

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