P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death

BACKGROUND: Extracellular adenosine triphosphate (ATP) functions as a novel danger signal that boosts antitumor immunity and can also directly kill tumor cells. We have previously reported that chronic exposure of tumor cells to ATP provokes P2X7-mediated tumor cell death, by as yet incompletely def...

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Detalles Bibliográficos
Autores principales: Bian, Shu, Sun, Xiaofeng, Bai, Aiping, Zhang, Chunqing, Li, Linglin, Enjyoji, Keiichi, Junger, Wolfgang G., Robson, Simon C., Wu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615040/
https://www.ncbi.nlm.nih.gov/pubmed/23565201
http://dx.doi.org/10.1371/journal.pone.0060184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615040/
https://www.ncbi.nlm.nih.gov/pubmed/23565201
http://dx.doi.org/10.1371/journal.pone.0060184

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