Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening

Heat shock protein 90 (Hsp90), whose inhibitors have shown promising activity in clinical trials, is an attractive anticancer target. In this work, we first explored the significant pharmacophore features needed for Hsp90 inhibitors by generating a 3D-QSAR pharmacophore model. It was then used to vi...

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Detalles Bibliográficos
Autores principales: Jia, JianMin, Xu, XiaoLi, Liu, Fang, Guo, XiaoKe, Zhang, MingYe, Lu, MengChen, Xu, LiLi, Wei, JinLian, Zhu, Jia, Zhang, ShengLie, Zhang, ShengMiao, Sun, HaoPeng, You, QiDong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615092/
https://www.ncbi.nlm.nih.gov/pubmed/23565147
http://dx.doi.org/10.1371/journal.pone.0059315

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