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Answering the ultimate question “What is the Proximal Cause of Aging?”

Recent discoveries suggest that aging is neither driven by accumulation of molecular damage of any cause, nor by random damage of any kind. Some predictions of a new theory, quasi-programmed hyperfunction, have already been confirmed and a clinically-available drug slows aging and delays diseases in...

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Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615154/
https://www.ncbi.nlm.nih.gov/pubmed/23425777
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
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description Recent discoveries suggest that aging is neither driven by accumulation of molecular damage of any cause, nor by random damage of any kind. Some predictions of a new theory, quasi-programmed hyperfunction, have already been confirmed and a clinically-available drug slows aging and delays diseases in animals. The relationship between diseases and aging becomes easily apparent. Yet, the essence of aging turns out to be so startling that the theory cannot be instantly accepted and any possible arguments are raised for its disposal. I discuss that these arguments actually support a new theory. Are any questions remaining? And might accumulation of molecular damage still play a peculiar role in aging?
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spelling pubmed-36151542013-04-05 Answering the ultimate question “What is the Proximal Cause of Aging?” Blagosklonny, Mikhail V. Aging (Albany NY) Review Recent discoveries suggest that aging is neither driven by accumulation of molecular damage of any cause, nor by random damage of any kind. Some predictions of a new theory, quasi-programmed hyperfunction, have already been confirmed and a clinically-available drug slows aging and delays diseases in animals. The relationship between diseases and aging becomes easily apparent. Yet, the essence of aging turns out to be so startling that the theory cannot be instantly accepted and any possible arguments are raised for its disposal. I discuss that these arguments actually support a new theory. Are any questions remaining? And might accumulation of molecular damage still play a peculiar role in aging? Impact Journals LLC 2012-12-30 /pmc/articles/PMC3615154/ /pubmed/23425777 Text en Copyright: © 2012 Blagosklonny http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Review
Blagosklonny, Mikhail V.
Answering the ultimate question “What is the Proximal Cause of Aging?”
title Answering the ultimate question “What is the Proximal Cause of Aging?”
title_full Answering the ultimate question “What is the Proximal Cause of Aging?”
title_fullStr Answering the ultimate question “What is the Proximal Cause of Aging?”
title_full_unstemmed Answering the ultimate question “What is the Proximal Cause of Aging?”
title_short Answering the ultimate question “What is the Proximal Cause of Aging?”
title_sort answering the ultimate question “what is the proximal cause of aging?”
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615154/
https://www.ncbi.nlm.nih.gov/pubmed/23425777
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