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P73 and age-related diseases: is there any link with Parkinson Disease?
P73 is a member of the p53 transcription factors family with a prominent role in neurobiology, affecting brain development as well as controlling neuronal survival. Accordingly, p73 has been identified as key player in many age-related neurodegenerative diseases, such as Alzheimer's disease, ne...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615159/ https://www.ncbi.nlm.nih.gov/pubmed/23271007 |
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author | Grespi, Francesca Melino, Gerry |
author_facet | Grespi, Francesca Melino, Gerry |
author_sort | Grespi, Francesca |
collection | PubMed |
description | P73 is a member of the p53 transcription factors family with a prominent role in neurobiology, affecting brain development as well as controlling neuronal survival. Accordingly, p73 has been identified as key player in many age-related neurodegenerative diseases, such as Alzheimer's disease, neuroAIDS and Niemann-Pick type C disease. Here we investigate possible correlations of p73 with Parkinson disease. Tyrosine hydroxylase is a crucial player in Parkinson disease being the enzyme necessary for dopamine synthesis. In this work we show that levels of tyrosine hydroxylase can be influenced by p73. We also demonstrate that p73 can protect against tyrosine hydroxylase depletion in an in vitro model of Parkinson disease. |
format | Online Article Text |
id | pubmed-3615159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-36151592013-04-05 P73 and age-related diseases: is there any link with Parkinson Disease? Grespi, Francesca Melino, Gerry Aging (Albany NY) Research Paper P73 is a member of the p53 transcription factors family with a prominent role in neurobiology, affecting brain development as well as controlling neuronal survival. Accordingly, p73 has been identified as key player in many age-related neurodegenerative diseases, such as Alzheimer's disease, neuroAIDS and Niemann-Pick type C disease. Here we investigate possible correlations of p73 with Parkinson disease. Tyrosine hydroxylase is a crucial player in Parkinson disease being the enzyme necessary for dopamine synthesis. In this work we show that levels of tyrosine hydroxylase can be influenced by p73. We also demonstrate that p73 can protect against tyrosine hydroxylase depletion in an in vitro model of Parkinson disease. Impact Journals LLC 2012-12-18 /pmc/articles/PMC3615159/ /pubmed/23271007 Text en Copyright: © 2012 Grespi and Melino http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Research Paper Grespi, Francesca Melino, Gerry P73 and age-related diseases: is there any link with Parkinson Disease? |
title | P73 and age-related diseases: is there any link with Parkinson Disease? |
title_full | P73 and age-related diseases: is there any link with Parkinson Disease? |
title_fullStr | P73 and age-related diseases: is there any link with Parkinson Disease? |
title_full_unstemmed | P73 and age-related diseases: is there any link with Parkinson Disease? |
title_short | P73 and age-related diseases: is there any link with Parkinson Disease? |
title_sort | p73 and age-related diseases: is there any link with parkinson disease? |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615159/ https://www.ncbi.nlm.nih.gov/pubmed/23271007 |
work_keys_str_mv | AT grespifrancesca p73andagerelateddiseasesisthereanylinkwithparkinsondisease AT melinogerry p73andagerelateddiseasesisthereanylinkwithparkinsondisease |