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MR-1 blocks the megakaryocytic differentiation and transition of CML from chronic phase to blast crisis through MEK dephosphorylation

Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the Philadelphia chromosome as the sole genetic abnormality and the accumulation of mature cells in peripheral blood into blast crisis, which is characterized by the rapid expansion of myeloid- or lymphoid-differentiati...

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Detalles Bibliográficos
Autores principales:	Zhao, W, He, H, Ren, K, Li, B, Zhang, H, Lin, Y, Shao, R-g
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615218/ https://www.ncbi.nlm.nih.gov/pubmed/23542180 http://dx.doi.org/10.1038/bcj.2013.5

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