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Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011)
In sheep, susceptibility to scrapie is mainly determined by codons 136, 154, and 171 of the PRNP gene. Five haplotypes are usually present (ARR, ARQ, ARH, AHQ, and VRQ). The ARR haplotype confers the greatest resistance to classical scrapie while VRQ renders animals most susceptible. In 2004, the Eu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Veterinary Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615231/ https://www.ncbi.nlm.nih.gov/pubmed/23388443 http://dx.doi.org/10.4142/jvs.2013.14.1.45 |
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author | Dobly, Alexandre Van der Heyden, Sara Roels, Stefan |
author_facet | Dobly, Alexandre Van der Heyden, Sara Roels, Stefan |
author_sort | Dobly, Alexandre |
collection | PubMed |
description | In sheep, susceptibility to scrapie is mainly determined by codons 136, 154, and 171 of the PRNP gene. Five haplotypes are usually present (ARR, ARQ, ARH, AHQ, and VRQ). The ARR haplotype confers the greatest resistance to classical scrapie while VRQ renders animals most susceptible. In 2004, the European Union implemented a breeding program that promotes selection of the ARR haplotype while reducing the incidence of VRQ. From 2006 to 2011 in Belgium, frequency for the ARR/ARR genotypes increased from 38.3% to 63.8% (n = 6,437), the ARQ haplotype diminished from 21.1% to 12.9%, and the VRQ haplotype decreased from 2.0% to 1.7%. The status of codon 141, a determinant for atypical scrapie, was also evaluated. Out of 27 different breeds (n = 5,163), nine were abundant. The ARR/ARR frequency increased in eight of these nine major breeds. The selection program has had a major impact on the ARR haplotype frequency in Belgium. However, the occurrence of atypical scrapie represents a critical point for this program that warrants the continuous monitoring of scrapie. Additionally, genotype frequencies among the breeds varied greatly. Texel, a breed that is common in Belgium, can still be selected for due to its average ARR frequency. |
format | Online Article Text |
id | pubmed-3615231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36152312013-04-08 Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011) Dobly, Alexandre Van der Heyden, Sara Roels, Stefan J Vet Sci Original Article In sheep, susceptibility to scrapie is mainly determined by codons 136, 154, and 171 of the PRNP gene. Five haplotypes are usually present (ARR, ARQ, ARH, AHQ, and VRQ). The ARR haplotype confers the greatest resistance to classical scrapie while VRQ renders animals most susceptible. In 2004, the European Union implemented a breeding program that promotes selection of the ARR haplotype while reducing the incidence of VRQ. From 2006 to 2011 in Belgium, frequency for the ARR/ARR genotypes increased from 38.3% to 63.8% (n = 6,437), the ARQ haplotype diminished from 21.1% to 12.9%, and the VRQ haplotype decreased from 2.0% to 1.7%. The status of codon 141, a determinant for atypical scrapie, was also evaluated. Out of 27 different breeds (n = 5,163), nine were abundant. The ARR/ARR frequency increased in eight of these nine major breeds. The selection program has had a major impact on the ARR haplotype frequency in Belgium. However, the occurrence of atypical scrapie represents a critical point for this program that warrants the continuous monitoring of scrapie. Additionally, genotype frequencies among the breeds varied greatly. Texel, a breed that is common in Belgium, can still be selected for due to its average ARR frequency. The Korean Society of Veterinary Science 2013-03 2013-03-24 /pmc/articles/PMC3615231/ /pubmed/23388443 http://dx.doi.org/10.4142/jvs.2013.14.1.45 Text en © 2013 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dobly, Alexandre Van der Heyden, Sara Roels, Stefan Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011) |
title | Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011) |
title_full | Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011) |
title_fullStr | Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011) |
title_full_unstemmed | Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011) |
title_short | Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011) |
title_sort | trends in genotype frequency resulting from breeding for resistance to classical scrapie in belgium (2006~2011) |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615231/ https://www.ncbi.nlm.nih.gov/pubmed/23388443 http://dx.doi.org/10.4142/jvs.2013.14.1.45 |
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