Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation

Simple, accurate and precise spectrophotometric methods have been developed for the determination of saxagliptin in bulk and dosage forms. The proposed methods are based on the charge transfer complexes of saxagliptin with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodi...

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Detalles Bibliográficos
Autores principales: El-Bagary, Ramzia I., Elkady, Ehab F., Ayoub, Bassam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615277/
https://www.ncbi.nlm.nih.gov/pubmed/23675274
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author El-Bagary, Ramzia I.
Elkady, Ehab F.
Ayoub, Bassam M.
author_facet El-Bagary, Ramzia I.
Elkady, Ehab F.
Ayoub, Bassam M.
author_sort El-Bagary, Ramzia I.
collection PubMed
description Simple, accurate and precise spectrophotometric methods have been developed for the determination of saxagliptin in bulk and dosage forms. The proposed methods are based on the charge transfer complexes of saxagliptin with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). All the variables were studied to optimize the reactions’ conditions. Beer’s law was obeyed in the concentration ranges of 50-300 μg/ml and 10-110 μg/ml with DDQ and TCNQ, respectively. The developed methods were validated and proved to be precise and accurate for the quality control of the saxagliptinin its pharmaceutical dosage form.
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spelling pubmed-36152772013-05-01 Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation El-Bagary, Ramzia I. Elkady, Ehab F. Ayoub, Bassam M. Int J Biomed Sci Article Simple, accurate and precise spectrophotometric methods have been developed for the determination of saxagliptin in bulk and dosage forms. The proposed methods are based on the charge transfer complexes of saxagliptin with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). All the variables were studied to optimize the reactions’ conditions. Beer’s law was obeyed in the concentration ranges of 50-300 μg/ml and 10-110 μg/ml with DDQ and TCNQ, respectively. The developed methods were validated and proved to be precise and accurate for the quality control of the saxagliptinin its pharmaceutical dosage form. Master Publishing Group 2012-09 /pmc/articles/PMC3615277/ /pubmed/23675274 Text en © Ramzia I. El-Bagary et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
El-Bagary, Ramzia I.
Elkady, Ehab F.
Ayoub, Bassam M.
Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation
title Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation
title_full Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation
title_fullStr Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation
title_full_unstemmed Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation
title_short Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation
title_sort spectrophotometric methods based on charge transfer complexation reactions for the determination of saxagliptin in bulk and pharmaceutical preparation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615277/
https://www.ncbi.nlm.nih.gov/pubmed/23675274
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