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Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV)

Functioning as an extracellular protease, dipeptidyl peptidase IV (DPP-IV) preferentially cleaves the peptide bond after the penultimate proline residue. We report here that DPP-IV cleaves the first two amino acids from insulin-like growth factor 1 (IGF-1), revealed by mass spectrometry. The kinetic...

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Detalles Bibliográficos
Autores principales:	Lin, Ching-Ting, Tang, Hsiang-Yun, Han, Yu-San, Liu, Hui-Ping, Huang, Shiu-Feng, Chien, Chia-Hui, Shyy, John, Chiu, Jeng-Jian, Chen, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Master Publishing Group 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615292/ https://www.ncbi.nlm.nih.gov/pubmed/23675206

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