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Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus
Pandemic H1N1/2009 viruses have been stabilized in swine herds, and some strains display higher pathogenicity than the human-origin isolates. In this study, high-throughput RNA sequencing (RNA-seq) is applied to explore the systemic transcriptome responses of the mouse lungs infected by swine (Jia6/...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615340/ https://www.ncbi.nlm.nih.gov/pubmed/23549303 http://dx.doi.org/10.1038/srep01601 |
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author | Zou, Wei Chen, Dijun Xiong, Min Zhu, Jiping Lin, Xian Wang, Lun Zhang, Jun Chen, Lingling Zhang, Hongyu Chen, Huanchun Chen, Ming Jin, Meilin |
author_facet | Zou, Wei Chen, Dijun Xiong, Min Zhu, Jiping Lin, Xian Wang, Lun Zhang, Jun Chen, Lingling Zhang, Hongyu Chen, Huanchun Chen, Ming Jin, Meilin |
author_sort | Zou, Wei |
collection | PubMed |
description | Pandemic H1N1/2009 viruses have been stabilized in swine herds, and some strains display higher pathogenicity than the human-origin isolates. In this study, high-throughput RNA sequencing (RNA-seq) is applied to explore the systemic transcriptome responses of the mouse lungs infected by swine (Jia6/10) and human (LN/09) H1N1/2009 viruses. The transcriptome data show that Jia6/10 activates stronger virus-sensing signals, such as the toll-like receptor, RIG-I like receptor and NOD-like receptor signalings, as well as a stronger NF-κB and JAK-STAT singals, which play significant roles in inducing innate immunity. Most cytokines and interferon-stimulated genes show higher expression lever in Jia/06 infected groups. Meanwhile, virus Jia6/10 activates stronger production of reactive oxygen species, which might further promote higher mutation rate of the virus genome. Collectively, our data reveal that the swine-origin pandemic H1N1/2009 virus elicits a stronger innate immune reaction and pro-oxidation stimulation, which might relate closely to the increasing pathogenicity. |
format | Online Article Text |
id | pubmed-3615340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36153402013-04-04 Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus Zou, Wei Chen, Dijun Xiong, Min Zhu, Jiping Lin, Xian Wang, Lun Zhang, Jun Chen, Lingling Zhang, Hongyu Chen, Huanchun Chen, Ming Jin, Meilin Sci Rep Article Pandemic H1N1/2009 viruses have been stabilized in swine herds, and some strains display higher pathogenicity than the human-origin isolates. In this study, high-throughput RNA sequencing (RNA-seq) is applied to explore the systemic transcriptome responses of the mouse lungs infected by swine (Jia6/10) and human (LN/09) H1N1/2009 viruses. The transcriptome data show that Jia6/10 activates stronger virus-sensing signals, such as the toll-like receptor, RIG-I like receptor and NOD-like receptor signalings, as well as a stronger NF-κB and JAK-STAT singals, which play significant roles in inducing innate immunity. Most cytokines and interferon-stimulated genes show higher expression lever in Jia/06 infected groups. Meanwhile, virus Jia6/10 activates stronger production of reactive oxygen species, which might further promote higher mutation rate of the virus genome. Collectively, our data reveal that the swine-origin pandemic H1N1/2009 virus elicits a stronger innate immune reaction and pro-oxidation stimulation, which might relate closely to the increasing pathogenicity. Nature Publishing Group 2013-04-03 /pmc/articles/PMC3615340/ /pubmed/23549303 http://dx.doi.org/10.1038/srep01601 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Zou, Wei Chen, Dijun Xiong, Min Zhu, Jiping Lin, Xian Wang, Lun Zhang, Jun Chen, Lingling Zhang, Hongyu Chen, Huanchun Chen, Ming Jin, Meilin Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus |
title | Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus |
title_full | Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus |
title_fullStr | Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus |
title_full_unstemmed | Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus |
title_short | Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus |
title_sort | insights into the increasing virulence of the swine-origin pandemic h1n1/2009 influenza virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615340/ https://www.ncbi.nlm.nih.gov/pubmed/23549303 http://dx.doi.org/10.1038/srep01601 |
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