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Phantom pain is associated with preserved structure and function in the former hand area

Phantom pain after arm amputation is widely believed to arise from maladaptive cortical reorganization, triggered by loss of sensory input. We instead propose that chronic phantom pain experience drives plasticity by maintaining local cortical representations and disrupting inter-regional connectivi...

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Autores principales: Makin, Tamar R., Scholz, Jan, Filippini, Nicola, Henderson Slater, David, Tracey, Irene, Johansen-Berg, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615341/
https://www.ncbi.nlm.nih.gov/pubmed/23463013
http://dx.doi.org/10.1038/ncomms2571
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author Makin, Tamar R.
Scholz, Jan
Filippini, Nicola
Henderson Slater, David
Tracey, Irene
Johansen-Berg, Heidi
author_facet Makin, Tamar R.
Scholz, Jan
Filippini, Nicola
Henderson Slater, David
Tracey, Irene
Johansen-Berg, Heidi
author_sort Makin, Tamar R.
collection PubMed
description Phantom pain after arm amputation is widely believed to arise from maladaptive cortical reorganization, triggered by loss of sensory input. We instead propose that chronic phantom pain experience drives plasticity by maintaining local cortical representations and disrupting inter-regional connectivity. Here we show that, while loss of sensory input is generally characterized by structural and functional degeneration in the deprived sensorimotor cortex, the experience of persistent pain is associated with preserved structure and functional organization in the former hand area. Furthermore, consistent with the isolated nature of phantom experience, phantom pain is associated with reduced inter-regional functional connectivity in the primary sensorimotor cortex. We therefore propose that contrary to the maladaptive model, cortical plasticity associated with phantom pain is driven by powerful and long-lasting subjective sensory experience, such as triggered by nociceptive or top–down inputs. Our results prompt a revisiting of the link between phantom pain and brain organization.
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spelling pubmed-36153412013-04-03 Phantom pain is associated with preserved structure and function in the former hand area Makin, Tamar R. Scholz, Jan Filippini, Nicola Henderson Slater, David Tracey, Irene Johansen-Berg, Heidi Nat Commun Article Phantom pain after arm amputation is widely believed to arise from maladaptive cortical reorganization, triggered by loss of sensory input. We instead propose that chronic phantom pain experience drives plasticity by maintaining local cortical representations and disrupting inter-regional connectivity. Here we show that, while loss of sensory input is generally characterized by structural and functional degeneration in the deprived sensorimotor cortex, the experience of persistent pain is associated with preserved structure and functional organization in the former hand area. Furthermore, consistent with the isolated nature of phantom experience, phantom pain is associated with reduced inter-regional functional connectivity in the primary sensorimotor cortex. We therefore propose that contrary to the maladaptive model, cortical plasticity associated with phantom pain is driven by powerful and long-lasting subjective sensory experience, such as triggered by nociceptive or top–down inputs. Our results prompt a revisiting of the link between phantom pain and brain organization. Nature Pub. Group 2013-03-05 /pmc/articles/PMC3615341/ /pubmed/23463013 http://dx.doi.org/10.1038/ncomms2571 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Makin, Tamar R.
Scholz, Jan
Filippini, Nicola
Henderson Slater, David
Tracey, Irene
Johansen-Berg, Heidi
Phantom pain is associated with preserved structure and function in the former hand area
title Phantom pain is associated with preserved structure and function in the former hand area
title_full Phantom pain is associated with preserved structure and function in the former hand area
title_fullStr Phantom pain is associated with preserved structure and function in the former hand area
title_full_unstemmed Phantom pain is associated with preserved structure and function in the former hand area
title_short Phantom pain is associated with preserved structure and function in the former hand area
title_sort phantom pain is associated with preserved structure and function in the former hand area
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615341/
https://www.ncbi.nlm.nih.gov/pubmed/23463013
http://dx.doi.org/10.1038/ncomms2571
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