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Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells

Epidemiological data support the concept that phenols and polyphenols in diet are safe and nontoxic, and have long-lasting beneficial effects on human health. The potential target for complementary and alternative medicine (CAM) research has been on the discovery of natural compounds that can be use...

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Detalles Bibliográficos
Autores principales: Szliszka, Ewelina, Krol, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615595/
https://www.ncbi.nlm.nih.gov/pubmed/23573148
http://dx.doi.org/10.1155/2013/731940
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author Szliszka, Ewelina
Krol, Wojciech
author_facet Szliszka, Ewelina
Krol, Wojciech
author_sort Szliszka, Ewelina
collection PubMed
description Epidemiological data support the concept that phenols and polyphenols in diet are safe and nontoxic, and have long-lasting beneficial effects on human health. The potential target for complementary and alternative medicine (CAM) research has been on the discovery of natural compounds that can be used in the prevention and treatment of cancer. Propolis is one of the richest sources of plant phenolics (flavonoids and phenolic acids). The ethanolic extract of propolis (EEP) and its polyphenols possess immunomodulatory, chemopreventive, and antitumor effects. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a  naturally occurring anticancer agent that preferentially induces apoptosis in cancer cells and is not toxic to normal cells. Endogenous TRAIL plays a significant role in immunosurveillance and defense against cancer cells. However, as more tumor cells are reported to be resistant to TRAIL-mediated death, it is important to develop new strategies to overcome this resistance. EEP and polyphenols isolated from propolis have been shown to sensitize cancer cells to TRAIL-induced apoptosis. In this paper we demonstrate for the first time the crucial role of the main phenolics isolated from propolis in enhancing TRAIL-mediated death in tumor cells for cancer chemoprevention.
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spelling pubmed-36155952013-04-09 Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells Szliszka, Ewelina Krol, Wojciech Evid Based Complement Alternat Med Review Article Epidemiological data support the concept that phenols and polyphenols in diet are safe and nontoxic, and have long-lasting beneficial effects on human health. The potential target for complementary and alternative medicine (CAM) research has been on the discovery of natural compounds that can be used in the prevention and treatment of cancer. Propolis is one of the richest sources of plant phenolics (flavonoids and phenolic acids). The ethanolic extract of propolis (EEP) and its polyphenols possess immunomodulatory, chemopreventive, and antitumor effects. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a  naturally occurring anticancer agent that preferentially induces apoptosis in cancer cells and is not toxic to normal cells. Endogenous TRAIL plays a significant role in immunosurveillance and defense against cancer cells. However, as more tumor cells are reported to be resistant to TRAIL-mediated death, it is important to develop new strategies to overcome this resistance. EEP and polyphenols isolated from propolis have been shown to sensitize cancer cells to TRAIL-induced apoptosis. In this paper we demonstrate for the first time the crucial role of the main phenolics isolated from propolis in enhancing TRAIL-mediated death in tumor cells for cancer chemoprevention. Hindawi Publishing Corporation 2013 2013-03-19 /pmc/articles/PMC3615595/ /pubmed/23573148 http://dx.doi.org/10.1155/2013/731940 Text en Copyright © 2013 E. Szliszka and W. Krol. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Szliszka, Ewelina
Krol, Wojciech
Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells
title Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells
title_full Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells
title_fullStr Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells
title_full_unstemmed Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells
title_short Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells
title_sort polyphenols isolated from propolis augment trail-induced apoptosis in cancer cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615595/
https://www.ncbi.nlm.nih.gov/pubmed/23573148
http://dx.doi.org/10.1155/2013/731940
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