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NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors
N-methyl-𝒟-aspartate receptors (NMDAR) overactivation is linked to neurodegeneration. The current prevailing theory suggests that synaptic and extrasynaptic NMDAR (syn- and ex-NMDAR) impose counteracting effects on cell fate, and neuronal cell death is mainly mediated by the activation of ex-NMDAR....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615746/ https://www.ncbi.nlm.nih.gov/pubmed/23538441 http://dx.doi.org/10.1038/cddis.2013.82 |