Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined “Complementary Lethality”

A high mutation rate leading to tumor cell heterogeneity is a driver of malignancy in human cancers. Paradoxically, however, genomic instability can also render tumors vulnerable to therapeutic attack. Thus, targeting DNA repair may induce an intolerable level of DNA damage in tumor cells. BRCA2 med...

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Detalles Bibliográficos
Autores principales: Rytelewski, Mateusz, Ferguson, Peter J, Vareki, Saman Maleki, Figueredo, Rene, Vincent, Mark, Koropatnick, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615817/
https://www.ncbi.nlm.nih.gov/pubmed/23481354
http://dx.doi.org/10.1038/mtna.2013.7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615817/
https://www.ncbi.nlm.nih.gov/pubmed/23481354
http://dx.doi.org/10.1038/mtna.2013.7

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