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Targeting 20-HETE producing enzymes in cancer – rationale, pharmacology, and clinical potential

Studies demonstrate that lipid mediator 20-Hydroxyeicosatetraenoic acid (20-HETE) synthesis and signaling are associated with the growth of cancer cells in vitro and in vivo. Stable 20-HETE agonists promote the proliferation of cancer cells, whereas selective inhibitors of the 20-HETE-producing enzy...

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Detalles Bibliográficos
Autores principales: Alexanian, Anna, Sorokin, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615879/
https://www.ncbi.nlm.nih.gov/pubmed/23569388
http://dx.doi.org/10.2147/OTT.S31586

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