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Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man
BACKGROUND: Normal pressure hydrocephalus (NPH) is composed of gait abnormalities, urinary incontinence and decline in mentation. It is uncommonly induced by syphilitic infection. CASE REPORT: A 76 year-old male present with gait disturbances, urinary incontinence, declining vision and cognition, wi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615923/ https://www.ncbi.nlm.nih.gov/pubmed/23569521 http://dx.doi.org/10.12659/AJCR.883322 |
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author | Mok, Shaffer R.S. Punjabi, Vivek Shklar, David L. |
author_facet | Mok, Shaffer R.S. Punjabi, Vivek Shklar, David L. |
author_sort | Mok, Shaffer R.S. |
collection | PubMed |
description | BACKGROUND: Normal pressure hydrocephalus (NPH) is composed of gait abnormalities, urinary incontinence and decline in mentation. It is uncommonly induced by syphilitic infection. CASE REPORT: A 76 year-old male present with gait disturbances, urinary incontinence, declining vision and cognition, with a known diagnosis of NPH. He underwent therapeutic lumbar puncture (LP), which demonstrated leukocytosis and elevated protein. Venereal disease research laboratory testing (VDRL) was reactive in a 1:64 dilution with positive fluorescent Treponemal Antibody (FTA-Abs). The subject was treated with 14 days of Intravenous (IV) Penicillin 3 million units for 3 weeks and intramuscular benzathine PCN for 2 shots, with marked clinical improvement. CONCLUSIONS: The incidence of Tabes Dorsalis is limited in the age of penicillin, especially in subjects without HIV. Subjects are diagnosed with either LP RPR or VDRL, confirmed with FTA-Abs. Common treatment is IV PCN 1.4–3 mU for 10–14 days. |
format | Online Article Text |
id | pubmed-3615923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36159232013-04-08 Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man Mok, Shaffer R.S. Punjabi, Vivek Shklar, David L. Am J Case Rep Case Report BACKGROUND: Normal pressure hydrocephalus (NPH) is composed of gait abnormalities, urinary incontinence and decline in mentation. It is uncommonly induced by syphilitic infection. CASE REPORT: A 76 year-old male present with gait disturbances, urinary incontinence, declining vision and cognition, with a known diagnosis of NPH. He underwent therapeutic lumbar puncture (LP), which demonstrated leukocytosis and elevated protein. Venereal disease research laboratory testing (VDRL) was reactive in a 1:64 dilution with positive fluorescent Treponemal Antibody (FTA-Abs). The subject was treated with 14 days of Intravenous (IV) Penicillin 3 million units for 3 weeks and intramuscular benzathine PCN for 2 shots, with marked clinical improvement. CONCLUSIONS: The incidence of Tabes Dorsalis is limited in the age of penicillin, especially in subjects without HIV. Subjects are diagnosed with either LP RPR or VDRL, confirmed with FTA-Abs. Common treatment is IV PCN 1.4–3 mU for 10–14 days. International Scientific Literature, Inc. 2012-08-07 /pmc/articles/PMC3615923/ /pubmed/23569521 http://dx.doi.org/10.12659/AJCR.883322 Text en © Am J Case Rep, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Case Report Mok, Shaffer R.S. Punjabi, Vivek Shklar, David L. Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man |
title | Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man |
title_full | Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man |
title_fullStr | Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man |
title_full_unstemmed | Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man |
title_short | Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man |
title_sort | neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615923/ https://www.ncbi.nlm.nih.gov/pubmed/23569521 http://dx.doi.org/10.12659/AJCR.883322 |
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