Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism

Neuropathic pain elevates spinal anandamide (AEA) levels in a way further increased when URB597, an inhibitor of AEA hydrolysis by fatty acid amide hydrolase (FAAH), is injected intrathecally. Spinal AEA reduces neuropathic pain by acting at both cannabinoid CB1 receptors and transient receptor pote...

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Detalles Bibliográficos
Autores principales: Starowicz, Katarzyna, Makuch, Wioletta, Korostynski, Michal, Malek, Natalia, Slezak, Michal, Zychowska, Magdalena, Petrosino, Stefania, De Petrocellis, Luciano, Cristino, Luigia, Przewlocka, Barbara, Di Marzo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616060/
https://www.ncbi.nlm.nih.gov/pubmed/23573230
http://dx.doi.org/10.1371/journal.pone.0060040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616060/
https://www.ncbi.nlm.nih.gov/pubmed/23573230
http://dx.doi.org/10.1371/journal.pone.0060040

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