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Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism
Neuropathic pain elevates spinal anandamide (AEA) levels in a way further increased when URB597, an inhibitor of AEA hydrolysis by fatty acid amide hydrolase (FAAH), is injected intrathecally. Spinal AEA reduces neuropathic pain by acting at both cannabinoid CB1 receptors and transient receptor pote...
Autores principales: | Starowicz, Katarzyna, Makuch, Wioletta, Korostynski, Michal, Malek, Natalia, Slezak, Michal, Zychowska, Magdalena, Petrosino, Stefania, De Petrocellis, Luciano, Cristino, Luigia, Przewlocka, Barbara, Di Marzo, Vincenzo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616060/ https://www.ncbi.nlm.nih.gov/pubmed/23573230 http://dx.doi.org/10.1371/journal.pone.0060040 |
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