Multiple active centers of multi-subunit RNA polymerases

The active center of multi-subunit RNA polymerase consists of two modules, the Mg(2+) module, holding the catalytic Mg(2+) ion, and a module made of a flexible domain, the Trigger Loop. Uniquely, the “TL module” can be substituted by “alternative modules,” thus changing the catalytic properties of t...

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Detalles Bibliográficos
Autores principales: Yuzenkova, Yulia, Roghanian, Mohammad, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616080/
https://www.ncbi.nlm.nih.gov/pubmed/22771945
http://dx.doi.org/10.4161/trns.19887
Descripción
Sumario:The active center of multi-subunit RNA polymerase consists of two modules, the Mg(2+) module, holding the catalytic Mg(2+) ion, and a module made of a flexible domain, the Trigger Loop. Uniquely, the “TL module” can be substituted by “alternative modules,” thus changing the catalytic properties of the active center.

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