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Permanent neonatal diabetes mellitus
BACKGROUND: Neonatal diabetes is a rare cause of hyperglycemia, affecting 1: 500,000 births, with persistent hyperglycemia occurring in the first months of life lasting more than 2 weeks and requiring insulin. This condition in infants less than 6 months of age is considered as permanent neonatal di...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616180/ https://www.ncbi.nlm.nih.gov/pubmed/23569512 http://dx.doi.org/10.12659/AJCR.883242 |
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author | Al-Matary, Abdulrahman Hussain, Mushtaq Nahari, Ahmed Ali, Jaffar |
author_facet | Al-Matary, Abdulrahman Hussain, Mushtaq Nahari, Ahmed Ali, Jaffar |
author_sort | Al-Matary, Abdulrahman |
collection | PubMed |
description | BACKGROUND: Neonatal diabetes is a rare cause of hyperglycemia, affecting 1: 500,000 births, with persistent hyperglycemia occurring in the first months of life lasting more than 2 weeks and requiring insulin. This condition in infants less than 6 months of age is considered as permanent neonatal diabetes mellitus. CASE REPORT: A rare case of permanent neonatal diabetes mellitus presented with intrauterine growth retardation (IUGR; birth weight: 1460 grams; female), hyperglycemia, glycosuria, and mild dehydration, a normal Apgar score of 8 and 9 at 1 and 5 minutes, respectively. The parents, of consanguineous union, had no prior history of diabetes mellitus. Of their 4 children, the first child had a diagnosis similar to the patient (their last child). The patient was initially started on continuous infusion of insulin, and then switched to regular insulin subcutaneously, but response was sub-optimal. She was started on neutral protamine Hagedorn, following which her condition improved. She was discharged on neutral protamine Hagedorn with regular follow-up. CONCLUSIONS: In view of widespread consanguinity in Saudi Arabia it appears prudent and pertinent to suspect permanent neonatal diabetes mellitus following diagnosis of hyperglycemia in small-for-age infants, especially those with positive family history of diabetes. Close blood glucose monitoring is essential as long as hyperglycemia persists. Prolong follow-up is imperative. |
format | Online Article Text |
id | pubmed-3616180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36161802013-04-08 Permanent neonatal diabetes mellitus Al-Matary, Abdulrahman Hussain, Mushtaq Nahari, Ahmed Ali, Jaffar Am J Case Rep Case Report BACKGROUND: Neonatal diabetes is a rare cause of hyperglycemia, affecting 1: 500,000 births, with persistent hyperglycemia occurring in the first months of life lasting more than 2 weeks and requiring insulin. This condition in infants less than 6 months of age is considered as permanent neonatal diabetes mellitus. CASE REPORT: A rare case of permanent neonatal diabetes mellitus presented with intrauterine growth retardation (IUGR; birth weight: 1460 grams; female), hyperglycemia, glycosuria, and mild dehydration, a normal Apgar score of 8 and 9 at 1 and 5 minutes, respectively. The parents, of consanguineous union, had no prior history of diabetes mellitus. Of their 4 children, the first child had a diagnosis similar to the patient (their last child). The patient was initially started on continuous infusion of insulin, and then switched to regular insulin subcutaneously, but response was sub-optimal. She was started on neutral protamine Hagedorn, following which her condition improved. She was discharged on neutral protamine Hagedorn with regular follow-up. CONCLUSIONS: In view of widespread consanguinity in Saudi Arabia it appears prudent and pertinent to suspect permanent neonatal diabetes mellitus following diagnosis of hyperglycemia in small-for-age infants, especially those with positive family history of diabetes. Close blood glucose monitoring is essential as long as hyperglycemia persists. Prolong follow-up is imperative. International Scientific Literature, Inc. 2012-07-10 /pmc/articles/PMC3616180/ /pubmed/23569512 http://dx.doi.org/10.12659/AJCR.883242 Text en © Am J Case Rep, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Case Report Al-Matary, Abdulrahman Hussain, Mushtaq Nahari, Ahmed Ali, Jaffar Permanent neonatal diabetes mellitus |
title | Permanent neonatal diabetes mellitus |
title_full | Permanent neonatal diabetes mellitus |
title_fullStr | Permanent neonatal diabetes mellitus |
title_full_unstemmed | Permanent neonatal diabetes mellitus |
title_short | Permanent neonatal diabetes mellitus |
title_sort | permanent neonatal diabetes mellitus |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616180/ https://www.ncbi.nlm.nih.gov/pubmed/23569512 http://dx.doi.org/10.12659/AJCR.883242 |
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