Cargando…

Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice

Increased fat intake is known to be a major cause of prostate cancer. In this study, we investigated the effect of dietary high fat on prostate intraepithelial neoplasia using transgenic adenocarcinoma mouse prostate (TRAMP) mice. Six-week-old male TRAMP mice were fed AIN93G (control group, 4.0 kcal...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Sung-Hoon, Chang, Seo-Na, Baek, Min-Won, Kim, Dong-Jae, Na, Yi-Rang, Seok, Seung-Hyeok, Lee, Byoung-Hee, Kim, Kyung-Sul, Park, Jae-Hak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616208/
https://www.ncbi.nlm.nih.gov/pubmed/23573107
http://dx.doi.org/10.5625/lar.2013.29.1.39
_version_ 1782265121490337792
author Park, Sung-Hoon
Chang, Seo-Na
Baek, Min-Won
Kim, Dong-Jae
Na, Yi-Rang
Seok, Seung-Hyeok
Lee, Byoung-Hee
Kim, Kyung-Sul
Park, Jae-Hak
author_facet Park, Sung-Hoon
Chang, Seo-Na
Baek, Min-Won
Kim, Dong-Jae
Na, Yi-Rang
Seok, Seung-Hyeok
Lee, Byoung-Hee
Kim, Kyung-Sul
Park, Jae-Hak
author_sort Park, Sung-Hoon
collection PubMed
description Increased fat intake is known to be a major cause of prostate cancer. In this study, we investigated the effect of dietary high fat on prostate intraepithelial neoplasia using transgenic adenocarcinoma mouse prostate (TRAMP) mice. Six-week-old male TRAMP mice were fed AIN93G (control group, 4.0 kcal/kg, n=6) and AIN93G-HFD (experimental group, 4.8 kcal/kg, n=7) for 10 weeks. Prostate histopathology, urogenital tract (UGT) weight, epididymal white adipose tissue weight, argyrophilic nucleolar organizer regions (AgNORs) counts, and serum leptin levels were examined. AIN93G-HFD fed group showed progressed neoplastic lesions in the prostate (P<0.05) compared to AIN93G fed group. AIN93G-HFD intake resulted in a increase in the weight of UGT (P<0.05) and epididymal white adipose tissue. The number of Ag-NOR positive dots significantly increased in each prostate lobe and final serum leptin levels in AIN93G-HFD fed group were about twice those of AIN93G fed group (P<0.05). Dietary high fat was related to the prostate cancer progression in the early stage of TRAMP mice and increased serum leptin levels, suggesting that the regulation of dietary components could delay the progression of prostate cancer.
format Online
Article
Text
id pubmed-3616208
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Korean Association for Laboratory Animal Science
record_format MEDLINE/PubMed
spelling pubmed-36162082013-04-09 Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice Park, Sung-Hoon Chang, Seo-Na Baek, Min-Won Kim, Dong-Jae Na, Yi-Rang Seok, Seung-Hyeok Lee, Byoung-Hee Kim, Kyung-Sul Park, Jae-Hak Lab Anim Res Original Article Increased fat intake is known to be a major cause of prostate cancer. In this study, we investigated the effect of dietary high fat on prostate intraepithelial neoplasia using transgenic adenocarcinoma mouse prostate (TRAMP) mice. Six-week-old male TRAMP mice were fed AIN93G (control group, 4.0 kcal/kg, n=6) and AIN93G-HFD (experimental group, 4.8 kcal/kg, n=7) for 10 weeks. Prostate histopathology, urogenital tract (UGT) weight, epididymal white adipose tissue weight, argyrophilic nucleolar organizer regions (AgNORs) counts, and serum leptin levels were examined. AIN93G-HFD fed group showed progressed neoplastic lesions in the prostate (P<0.05) compared to AIN93G fed group. AIN93G-HFD intake resulted in a increase in the weight of UGT (P<0.05) and epididymal white adipose tissue. The number of Ag-NOR positive dots significantly increased in each prostate lobe and final serum leptin levels in AIN93G-HFD fed group were about twice those of AIN93G fed group (P<0.05). Dietary high fat was related to the prostate cancer progression in the early stage of TRAMP mice and increased serum leptin levels, suggesting that the regulation of dietary components could delay the progression of prostate cancer. Korean Association for Laboratory Animal Science 2013-03 2013-03-25 /pmc/articles/PMC3616208/ /pubmed/23573107 http://dx.doi.org/10.5625/lar.2013.29.1.39 Text en Copyright © 2013 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Sung-Hoon
Chang, Seo-Na
Baek, Min-Won
Kim, Dong-Jae
Na, Yi-Rang
Seok, Seung-Hyeok
Lee, Byoung-Hee
Kim, Kyung-Sul
Park, Jae-Hak
Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice
title Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice
title_full Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice
title_fullStr Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice
title_full_unstemmed Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice
title_short Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice
title_sort effects of dietary high fat on prostate intraepithelial neoplasia in tramp mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616208/
https://www.ncbi.nlm.nih.gov/pubmed/23573107
http://dx.doi.org/10.5625/lar.2013.29.1.39
work_keys_str_mv AT parksunghoon effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice
AT changseona effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice
AT baekminwon effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice
AT kimdongjae effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice
AT nayirang effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice
AT seokseunghyeok effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice
AT leebyounghee effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice
AT kimkyungsul effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice
AT parkjaehak effectsofdietaryhighfatonprostateintraepithelialneoplasiaintrampmice