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Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice
According to a high anti-osteoporotic efficacy of Sigma Anti-bonding Molecule Calcium Carbonate (SAC), repeated-dose toxicities of SAC were investigated to assess its feasibility as drug or functional food ingredient. Male ICR mice were given drinking water containing 0.006, 0.02 or 0.06% SAC for 4...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association for Laboratory Animal Science
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616211/ https://www.ncbi.nlm.nih.gov/pubmed/23573102 http://dx.doi.org/10.5625/lar.2013.29.1.7 |
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author | Jang, Ja-Young Cai, Jingmei Kim, Jihyun Kyung, Jangbeen Kim, Dajeong Choi, Ehn-Kyoung Kim, Youngeun Kim, Kwang-Sei Park, Dongsun Kang, Hyun-Gu Kim, Yun-Bae |
author_facet | Jang, Ja-Young Cai, Jingmei Kim, Jihyun Kyung, Jangbeen Kim, Dajeong Choi, Ehn-Kyoung Kim, Youngeun Kim, Kwang-Sei Park, Dongsun Kang, Hyun-Gu Kim, Yun-Bae |
author_sort | Jang, Ja-Young |
collection | PubMed |
description | According to a high anti-osteoporotic efficacy of Sigma Anti-bonding Molecule Calcium Carbonate (SAC), repeated-dose toxicities of SAC were investigated to assess its feasibility as drug or functional food ingredient. Male ICR mice were given drinking water containing 0.006, 0.02 or 0.06% SAC for 4 weeks. SAC feeding decreased the body weights and feed and water consumptions of mice in a dose-dependent manner, especially, leading to severe emaciation and 70% death in 3 weeks in the high-dose (0.06%) group. Not only kidney and heart weights, but also the levels of blood urea nitrogen, creatinine, aspartate transaminase, and creatine phospokinase significantly increased after SAC administration, indicative of nephrotoxicity and cardiotoxicity. Such renal and cardiac toxicities were also confirmed by microscopic findings, exhibiting renal crystals and cardiac fibrosis, which may be due to the insoluble crystal formation and calcium overload, respectively. In conclusion, it is suggested that no observed adverse effect level of SAC is lower than 0.006% in mice, and that a long-term intake may cause serious adverse effects on renal and cardiac functions. |
format | Online Article Text |
id | pubmed-3616211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36162112013-04-09 Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice Jang, Ja-Young Cai, Jingmei Kim, Jihyun Kyung, Jangbeen Kim, Dajeong Choi, Ehn-Kyoung Kim, Youngeun Kim, Kwang-Sei Park, Dongsun Kang, Hyun-Gu Kim, Yun-Bae Lab Anim Res Original Article According to a high anti-osteoporotic efficacy of Sigma Anti-bonding Molecule Calcium Carbonate (SAC), repeated-dose toxicities of SAC were investigated to assess its feasibility as drug or functional food ingredient. Male ICR mice were given drinking water containing 0.006, 0.02 or 0.06% SAC for 4 weeks. SAC feeding decreased the body weights and feed and water consumptions of mice in a dose-dependent manner, especially, leading to severe emaciation and 70% death in 3 weeks in the high-dose (0.06%) group. Not only kidney and heart weights, but also the levels of blood urea nitrogen, creatinine, aspartate transaminase, and creatine phospokinase significantly increased after SAC administration, indicative of nephrotoxicity and cardiotoxicity. Such renal and cardiac toxicities were also confirmed by microscopic findings, exhibiting renal crystals and cardiac fibrosis, which may be due to the insoluble crystal formation and calcium overload, respectively. In conclusion, it is suggested that no observed adverse effect level of SAC is lower than 0.006% in mice, and that a long-term intake may cause serious adverse effects on renal and cardiac functions. Korean Association for Laboratory Animal Science 2013-03 2013-03-25 /pmc/articles/PMC3616211/ /pubmed/23573102 http://dx.doi.org/10.5625/lar.2013.29.1.7 Text en Copyright © 2013 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jang, Ja-Young Cai, Jingmei Kim, Jihyun Kyung, Jangbeen Kim, Dajeong Choi, Ehn-Kyoung Kim, Youngeun Kim, Kwang-Sei Park, Dongsun Kang, Hyun-Gu Kim, Yun-Bae Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice |
title | Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice |
title_full | Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice |
title_fullStr | Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice |
title_full_unstemmed | Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice |
title_short | Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice |
title_sort | specific nephrotoxicity and cardiotoxicity of bt-cal®, sigma anti-bonding molecule calcium carbonate, in mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616211/ https://www.ncbi.nlm.nih.gov/pubmed/23573102 http://dx.doi.org/10.5625/lar.2013.29.1.7 |
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