Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

Oligonucleotides containing an immune-stimulatory motif and an immune-regulatory motif act as antagonists of Toll-like receptor (TLR)7 and TLR9. In the present study, we designed and synthesized oligonucleotide-based antagonists of TLR7, 8 and 9 containing a 7-deaza-dG or arabino-G modification in t...

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Detalles Bibliográficos
Autores principales: Kandimalla, Ekambar R., Bhagat, Lakshmi, Wang, Daqing, Yu, Dong, Sullivan, Tim, La Monica, Nicola, Agrawal, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616729/
https://www.ncbi.nlm.nih.gov/pubmed/23396449
http://dx.doi.org/10.1093/nar/gkt078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616729/
https://www.ncbi.nlm.nih.gov/pubmed/23396449
http://dx.doi.org/10.1093/nar/gkt078

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