Cargando…

Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions

Recent experiments provided controversial observations that either parallel or non-parallel G-quadruplex exists in molecularly crowded buffers that mimic cellular environment. Here, we used laser tweezers to mechanically unfold structures in a human telomeric DNA fragment, 5′-(TTAGGG)(4)TTA, along t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dhakal, Soma, Cui, Yunxi, Koirala, Deepak, Ghimire, Chiran, Kushwaha, Saurabh, Yu, Zhongbo, Yangyuoru, Philip M., Mao, Hanbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616730/ https://www.ncbi.nlm.nih.gov/pubmed/23396442 http://dx.doi.org/10.1093/nar/gkt038

Ejemplares similares

Direct experimental evidence for quadruplex–quadruplex interaction within the human ILPR
por: Schonhoft, Joseph D., et al.
Publicado: (2009)

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex**
por: Yangyuoru, Philip M, et al.
Publicado: (2015)

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex**
por: Yangyuoru, Philip M, et al.
Publicado: (2015)

Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL
por: Cui, Yunxi, et al.
Publicado: (2014)

The solution structures of higher-order human telomere G-quadruplex multimers
por: Monsen, Robert C, et al.
Publicado: (2021)

Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K(+) solution: insights into the interconversion of human telomeric G-quadruplex structures
por: Zhang, Zhenjiang, et al.
Publicado: (2010)

G-quadruplex formation in human telomeric (TTAGGG)(4) sequence with complementary strand in close vicinity under molecularly crowded condition
por: Kan, Zhong-yuan, et al.
Publicado: (2007)

Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K(+) solution
por: Phan, Anh Tuân, et al.
Publicado: (2006)

Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K(+) solution(†)
por: Phan, Anh Tuân, et al.
Publicado: (2007)

Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation
por: Dai, Jixun, et al.
Publicado: (2007)

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K(+) solution: insights into structure polymorphism of the human telomeric sequence
por: Dai, Jixun, et al.
Publicado: (2007)

Arrangements of human telomere DNA quadruplex in physiologically relevant K(+) solutions
por: Renčiuk, D., et al.
Publicado: (2009)

Structure of the human telomere in Na(+) solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity
por: Lim, Kah Wai, et al.
Publicado: (2013)

Nascent RNA transcripts facilitate the formation of G-quadruplexes
por: Shrestha, Prakash, et al.
Publicado: (2014)

Intramolecular Folding in Human ILPR Fragment with Three C-Rich Repeats
por: Dhakal, Soma, et al.
Publicado: (2012)

Dynamics and stability of polymorphic human telomeric G-quadruplex under tension
por: You, Huijuan, et al.
Publicado: (2014)

Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein
por: Amato, Jussara, et al.
Publicado: (2019)

Involvement of G-triplex and G-hairpin in the multi-pathway folding of human telomeric G-quadruplex
por: Hou, Xi-Miao, et al.
Publicado: (2017)

Folding dynamics and conformational heterogeneity of human telomeric G-quadruplex structures in Na(+) solutions by single molecule FRET microscopy
por: Noer, Sofie L., et al.
Publicado: (2016)

G-quadruplex preferentially forms at the very 3′ end of vertebrate telomeric DNA
por: Tang, Jun, et al.
Publicado: (2008)

A direct view of the complex multi-pathway folding of telomeric G-quadruplexes
por: Aznauryan, Mikayel, et al.
Publicado: (2016)

Pre-folded structures govern folding pathways of human telomeric G-quadruplexes
por: Frelih, Tjaša, et al.
Publicado: (2020)

Divalent cations and molecular crowding buffers stabilize G-triplex at physiologically relevant temperatures
por: Jiang, Hong-Xin, et al.
Publicado: (2015)

Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNA
por: Zheng, Ke-wei, et al.
Publicado: (2010)

The effect of the TRF2 N-terminal and TRFH regions on telomeric G-quadruplex structures
por: Pedroso, Ilene M., et al.
Publicado: (2009)

Dramatic effect of single-base mutation on the conformational dynamics of human telomeric G-quadruplex
por: Lee, Ja Yil, et al.
Publicado: (2009)

Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection
por: Buscaglia, Robert, et al.
Publicado: (2013)

Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1
por: Traczyk, Anna, et al.
Publicado: (2020)

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K(+): insights into loop interactions of the parallel G-quadruplexes
por: Agrawal, Prashansa, et al.
Publicado: (2013)

A novel chair-type G-quadruplex formed by a Bombyx mori telomeric sequence
por: Amrane, Samir, et al.
Publicado: (2009)

Kinetics and mechanism of K(+)- and Na(+)-induced folding of models of human telomeric DNA into G-quadruplex structures
por: Gray, Robert D., et al.
Publicado: (2008)

Mechanical unfolding of human telomere G-quadruplex DNA probed by integrated fluorescence and magnetic tweezers spectroscopy
por: Long, Xi, et al.
Publicado: (2013)

The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA
por: Geng, Yanyan, et al.
Publicado: (2019)

Kinetically governed polymorphism of d(G(4)T(4)G(3)) quadruplexes in K(+) solutions
por: Prislan, Iztok, et al.
Publicado: (2011)

Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad
por: Lim, Kah Wai, et al.
Publicado: (2009)

Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops
por: Marušič, Maja, et al.
Publicado: (2012)

Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA
por: Barbieri, Christopher M., et al.
Publicado: (2007)

G-quadruplex formation at the 3′ end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase
por: Wang, Quan, et al.
Publicado: (2011)

The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions
por: Hänsel, Robert, et al.
Publicado: (2011)

Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences
por: Gaynutdinov, Timur I., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_a4ctg2lhu9ta3ssv13nuhcmkga