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Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 interactions with lentiviral integrases are well characterized, but the structural basis for how LEDGF/p75 engages chromatin i...

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Detalles Bibliográficos
Autores principales:	Eidahl, Jocelyn O., Crowe, Brandon L., North, Justin A., McKee, Christopher J., Shkriabai, Nikoloz, Feng, Lei, Plumb, Matthew, Graham, Robert L., Gorelick, Robert J., Hess, Sonja, Poirier, Michael G., Foster, Mark P., Kvaratskhelia, Mamuka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616739/ https://www.ncbi.nlm.nih.gov/pubmed/23396443 http://dx.doi.org/10.1093/nar/gkt074

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