Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action

BACKGROUND: The discovery and development of anti-malarial compounds of plant origin and semisynthetic derivatives thereof, such as quinine (QN) and chloroquine (CQ), has highlighted the importance of these compounds in the treatment of malaria. Ursolic acid analogues bearing an acetyl group at C-3...

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Detalles Bibliográficos
Autores principales: da Silva, Gloria NS, Maria, Nicole RG, Schuck, Desirée C, Cruz, Laura N, de Moraes, Miriam S, Nakabashi, Myna, Graebin, Cedric, Gosmann, Grace, Garcia, Célia RS, Gnoatto, Simone CB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616855/
https://www.ncbi.nlm.nih.gov/pubmed/23497003
http://dx.doi.org/10.1186/1475-2875-12-89

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