Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1

The mediators of the DNA damage response (DDR) are highly phosphorylated by kinases that control cell proliferation, but little is known about the role of this regulation. Here we show that cell cycle phosphorylation of the prototypical DDR mediator Saccharomyces cerevisiae Rad9 depends on cyclin-de...

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Detalles Bibliográficos
Autores principales: Abreu, Carla Manuela, Kumar, Ramesh, Hamilton, Danielle, Dawdy, Andrew William, Creavin, Kevin, Eivers, Sarah, Finn, Karen, Balsbaugh, Jeremy Lynn, O'Connor, Rosemary, Kiely, Patrick A., Shabanowitz, Jeffrey, Hunt, Donald F., Grenon, Muriel, Lowndes, Noel Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616908/
https://www.ncbi.nlm.nih.gov/pubmed/23593009
http://dx.doi.org/10.1371/journal.pgen.1003310

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