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The Environment Affects Epistatic Interactions to Alter the Topology of an Empirical Fitness Landscape
The fitness effect of mutations can be influenced by their interactions with the environment, other mutations, or both. Previously, we constructed 32 ( = 2(5)) genotypes that comprise all possible combinations of the first five beneficial mutations to fix in a laboratory-evolved population of Escher...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616912/ https://www.ncbi.nlm.nih.gov/pubmed/23593024 http://dx.doi.org/10.1371/journal.pgen.1003426 |