Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure

The Janus Kinase 2 (JAK2) plays essential roles in transmitting signals from multiple cytokine receptors, and constitutive activation of JAK2 results in hematopoietic disorders and oncogenesis. JAK2 kinase activity is negatively regulated by its pseudokinase domain (JH2), where the gain-of-function...

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Detalles Bibliográficos
Autores principales: Wan, Xiaobo, Ma, Yue, McClendon, Christopher L., Huang, Lily Jun-shen, Huang, Niu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616975/
https://www.ncbi.nlm.nih.gov/pubmed/23592968
http://dx.doi.org/10.1371/journal.pcbi.1003022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616975/
https://www.ncbi.nlm.nih.gov/pubmed/23592968
http://dx.doi.org/10.1371/journal.pcbi.1003022

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