3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer related death. It is lethal in nearly all patients, due to an almost complete chemoresistance. Most if not all drugs that pass preclinical tests successfully, fail miserably in the patient. This raises the...

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Detalles Bibliográficos
Autores principales: Longati, Paola, Jia, Xiaohui, Eimer, Johannes, Wagman, Annika, Witt, Michael-Robin, Rehnmark, Stefan, Verbeke, Caroline, Toftgård, Rune, Löhr, Matthias, Heuchel, Rainer L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617005/
https://www.ncbi.nlm.nih.gov/pubmed/23446043
http://dx.doi.org/10.1186/1471-2407-13-95

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