Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/2 Mouse Model of HD

Huntington’s disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6/2 mouse model of HD expresses a mutant version of exon 1 HTT and develops motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Despite the vast n...

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Detalles Bibliográficos
Autores principales: Rattray, Ivan, Smith, Edward, Gale, Richard, Matsumoto, Kaoru, Bates, Gillian P., Modo, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617160/
https://www.ncbi.nlm.nih.gov/pubmed/23593159
http://dx.doi.org/10.1371/journal.pone.0060012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617160/
https://www.ncbi.nlm.nih.gov/pubmed/23593159
http://dx.doi.org/10.1371/journal.pone.0060012

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