Systems Modeling of Molecular Mechanisms Controlling Cytokine-driven CD4+ T Cell Differentiation and Phenotype Plasticity

Differentiation of CD4+ T cells into effector or regulatory phenotypes is tightly controlled by the cytokine milieu, complex intracellular signaling networks and numerous transcriptional regulators. We combined experimental approaches and computational modeling to investigate the mechanisms controll...

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Detalles Bibliográficos
Autores principales: Carbo, Adria, Hontecillas, Raquel, Kronsteiner, Barbara, Viladomiu, Monica, Pedragosa, Mireia, Lu, Pinyi, Philipson, Casandra W., Hoops, Stefan, Marathe, Madhav, Eubank, Stephen, Bisset, Keith, Wendelsdorf, Katherine, Jarrah, Abdul, Mei, Yongguo, Bassaganya-Riera, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617204/
https://www.ncbi.nlm.nih.gov/pubmed/23592971
http://dx.doi.org/10.1371/journal.pcbi.1003027

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