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Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy
Our objective was to evaluate the relationship between intrauterine exposure to cadmium and the presence of atopic dermatitis in infants 6 months of age, adjusted for covariates including exposure to other heavy metals. The present research is a component of the Mothers' and Children's Env...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617302/ https://www.ncbi.nlm.nih.gov/pubmed/23580123 http://dx.doi.org/10.3346/jkms.2013.28.4.516 |
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author | Kim, Ja Hyeong Jeong, Kyoung Sook Ha, Eun-Hee Park, Hyesook Ha, Mina Hong, Yun-Chul Lee, Soo-Jeong Lee, Kyung Yeon Jeong, Joseph Kim, Yangho |
author_facet | Kim, Ja Hyeong Jeong, Kyoung Sook Ha, Eun-Hee Park, Hyesook Ha, Mina Hong, Yun-Chul Lee, Soo-Jeong Lee, Kyung Yeon Jeong, Joseph Kim, Yangho |
author_sort | Kim, Ja Hyeong |
collection | PubMed |
description | Our objective was to evaluate the relationship between intrauterine exposure to cadmium and the presence of atopic dermatitis in infants 6 months of age, adjusted for covariates including exposure to other heavy metals. The present research is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project conducted in Korea. Study subjects were restricted to pregnant women in whom cadmium and lead levels were measured at delivery and whose infants were assessed for the presence of atopic disease at 6 months of age. The odds ratio (OR) for the presence of atopic dermatitis in 6-month-old infants whose cord blood had elevated cadmium levels, after adjustment for other covariates, was 2.350 (95% CI, 1.126-4.906). The OR for the presence of atopic dermatitis in infants whose cord blood had elevated lead levels was not significant. In the present study, the cord blood cadmium level was significantly associated with the presence of atopic dermatitis in 6-month-old infants; this was not true of the cord blood lead level. To the best of our knowledge, this is the first prospective study to show a relationship between prenatal exposure to cadmium and atopic dermatitis in infancy. |
format | Online Article Text |
id | pubmed-3617302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-36173022013-04-11 Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy Kim, Ja Hyeong Jeong, Kyoung Sook Ha, Eun-Hee Park, Hyesook Ha, Mina Hong, Yun-Chul Lee, Soo-Jeong Lee, Kyung Yeon Jeong, Joseph Kim, Yangho J Korean Med Sci Original Article Our objective was to evaluate the relationship between intrauterine exposure to cadmium and the presence of atopic dermatitis in infants 6 months of age, adjusted for covariates including exposure to other heavy metals. The present research is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project conducted in Korea. Study subjects were restricted to pregnant women in whom cadmium and lead levels were measured at delivery and whose infants were assessed for the presence of atopic disease at 6 months of age. The odds ratio (OR) for the presence of atopic dermatitis in 6-month-old infants whose cord blood had elevated cadmium levels, after adjustment for other covariates, was 2.350 (95% CI, 1.126-4.906). The OR for the presence of atopic dermatitis in infants whose cord blood had elevated lead levels was not significant. In the present study, the cord blood cadmium level was significantly associated with the presence of atopic dermatitis in 6-month-old infants; this was not true of the cord blood lead level. To the best of our knowledge, this is the first prospective study to show a relationship between prenatal exposure to cadmium and atopic dermatitis in infancy. The Korean Academy of Medical Sciences 2013-04 2013-03-27 /pmc/articles/PMC3617302/ /pubmed/23580123 http://dx.doi.org/10.3346/jkms.2013.28.4.516 Text en © 2013 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Ja Hyeong Jeong, Kyoung Sook Ha, Eun-Hee Park, Hyesook Ha, Mina Hong, Yun-Chul Lee, Soo-Jeong Lee, Kyung Yeon Jeong, Joseph Kim, Yangho Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy |
title | Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy |
title_full | Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy |
title_fullStr | Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy |
title_full_unstemmed | Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy |
title_short | Association between Prenatal Exposure to Cadmium and Atopic Dermatitis in Infancy |
title_sort | association between prenatal exposure to cadmium and atopic dermatitis in infancy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617302/ https://www.ncbi.nlm.nih.gov/pubmed/23580123 http://dx.doi.org/10.3346/jkms.2013.28.4.516 |
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