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Developments in the Identification of Glycan Biomarkers for the Detection of Cancer
Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The American Society for Biochemistry and Molecular Biology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617331/ https://www.ncbi.nlm.nih.gov/pubmed/23365456 http://dx.doi.org/10.1074/mcp.R112.026799 |
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author | Ruhaak, L. Renee Miyamoto, Suzanne Lebrilla, Carlito B. |
author_facet | Ruhaak, L. Renee Miyamoto, Suzanne Lebrilla, Carlito B. |
author_sort | Ruhaak, L. Renee |
collection | PubMed |
description | Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use. |
format | Online Article Text |
id | pubmed-3617331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-36173312013-05-29 Developments in the Identification of Glycan Biomarkers for the Detection of Cancer Ruhaak, L. Renee Miyamoto, Suzanne Lebrilla, Carlito B. Mol Cell Proteomics Review Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use. The American Society for Biochemistry and Molecular Biology 2013-04 2013-01-30 /pmc/articles/PMC3617331/ /pubmed/23365456 http://dx.doi.org/10.1074/mcp.R112.026799 Text en © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) applies to Author Choice Articles |
spellingShingle | Review Ruhaak, L. Renee Miyamoto, Suzanne Lebrilla, Carlito B. Developments in the Identification of Glycan Biomarkers for the Detection of Cancer |
title | Developments in the Identification of Glycan Biomarkers for the Detection of Cancer |
title_full | Developments in the Identification of Glycan Biomarkers for the Detection of Cancer |
title_fullStr | Developments in the Identification of Glycan Biomarkers for the Detection of Cancer |
title_full_unstemmed | Developments in the Identification of Glycan Biomarkers for the Detection of Cancer |
title_short | Developments in the Identification of Glycan Biomarkers for the Detection of Cancer |
title_sort | developments in the identification of glycan biomarkers for the detection of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617331/ https://www.ncbi.nlm.nih.gov/pubmed/23365456 http://dx.doi.org/10.1074/mcp.R112.026799 |
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