Strategies for Local Gene Therapy of Corneal Allograft Rejection

Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and phar...

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Detalles Bibliográficos
Autores principales: Nguyen, Pho, Yiu, Samuel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Symposium - Ocular Therapeutics of the Future
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617523/
https://www.ncbi.nlm.nih.gov/pubmed/23580848
http://dx.doi.org/10.4103/0974-9233.106382
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author Nguyen, Pho
Yiu, Samuel C.
author_facet Nguyen, Pho
Yiu, Samuel C.
author_sort Nguyen, Pho
collection PubMed
description Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and pharmacologic tools is available to improve graft survival. In this review, we will discuss the various gene therapeutic strategies aimed at potentiating the anterior chamber-associated immune deviation to extend graft survival.
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spelling pubmed-36175232013-04-11 Strategies for Local Gene Therapy of Corneal Allograft Rejection Nguyen, Pho Yiu, Samuel C. Middle East Afr J Ophthalmol Symposium - Ocular Therapeutics of the Future Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and pharmacologic tools is available to improve graft survival. In this review, we will discuss the various gene therapeutic strategies aimed at potentiating the anterior chamber-associated immune deviation to extend graft survival. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3617523/ /pubmed/23580848 http://dx.doi.org/10.4103/0974-9233.106382 Text en Copyright: © Middle East African Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Symposium - Ocular Therapeutics of the Future
Nguyen, Pho
Yiu, Samuel C.
Strategies for Local Gene Therapy of Corneal Allograft Rejection
title Strategies for Local Gene Therapy of Corneal Allograft Rejection
title_full Strategies for Local Gene Therapy of Corneal Allograft Rejection
title_fullStr Strategies for Local Gene Therapy of Corneal Allograft Rejection
title_full_unstemmed Strategies for Local Gene Therapy of Corneal Allograft Rejection
title_short Strategies for Local Gene Therapy of Corneal Allograft Rejection
title_sort strategies for local gene therapy of corneal allograft rejection
topic Symposium - Ocular Therapeutics of the Future
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617523/
https://www.ncbi.nlm.nih.gov/pubmed/23580848
http://dx.doi.org/10.4103/0974-9233.106382
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