Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient

BACKGROUND: The BRAF inhibitor vemurafenib is state of the art in therapy of patients with malignant melanoma in non-resectable stage III or stage IV and evidence of oncogenetic BRAF mutation. Multiple cutaneous side effects like rash and keratoacanthoma-like lesions have been described so far. CASE...

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Autores principales: Schmitt, Laurenz, Schumann, Tamara, Inhoff, Oliver, Löser, Christoph, Rebel, Martin, Dippel, Edgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: March, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617885/
https://www.ncbi.nlm.nih.gov/pubmed/23626542
http://dx.doi.org/10.1159/000350288
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author Schmitt, Laurenz
Schumann, Tamara
Inhoff, Oliver
Löser, Christoph
Rebel, Martin
Dippel, Edgar
author_facet Schmitt, Laurenz
Schumann, Tamara
Inhoff, Oliver
Löser, Christoph
Rebel, Martin
Dippel, Edgar
author_sort Schmitt, Laurenz
collection PubMed
description BACKGROUND: The BRAF inhibitor vemurafenib is state of the art in therapy of patients with malignant melanoma in non-resectable stage III or stage IV and evidence of oncogenetic BRAF mutation. Multiple cutaneous side effects like rash and keratoacanthoma-like lesions have been described so far. CASE REPORT: We report a patient who presented multiple wart-like lesions under therapy with vemurafenib. Histologically we have seen multiple melanocytic nevi with a wart-like appearance. One melanoma in situ developed on the left forearm. CONCLUSIONS: Eruptive nevi and induction of melanoma may be a further side effect in patients undergoing a therapy with BRAF inhibitors.
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spelling pubmed-36178852013-04-26 Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient Schmitt, Laurenz Schumann, Tamara Inhoff, Oliver Löser, Christoph Rebel, Martin Dippel, Edgar Case Rep Dermatol Published online: March, 2013 BACKGROUND: The BRAF inhibitor vemurafenib is state of the art in therapy of patients with malignant melanoma in non-resectable stage III or stage IV and evidence of oncogenetic BRAF mutation. Multiple cutaneous side effects like rash and keratoacanthoma-like lesions have been described so far. CASE REPORT: We report a patient who presented multiple wart-like lesions under therapy with vemurafenib. Histologically we have seen multiple melanocytic nevi with a wart-like appearance. One melanoma in situ developed on the left forearm. CONCLUSIONS: Eruptive nevi and induction of melanoma may be a further side effect in patients undergoing a therapy with BRAF inhibitors. S. Karger AG 2013-03-12 /pmc/articles/PMC3617885/ /pubmed/23626542 http://dx.doi.org/10.1159/000350288 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: March, 2013
Schmitt, Laurenz
Schumann, Tamara
Inhoff, Oliver
Löser, Christoph
Rebel, Martin
Dippel, Edgar
Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient
title Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient
title_full Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient
title_fullStr Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient
title_full_unstemmed Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient
title_short Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient
title_sort eruptive nevi mimicking wart-like lesions under selective braf inhibition in a 37-year-old female melanoma patient
topic Published online: March, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617885/
https://www.ncbi.nlm.nih.gov/pubmed/23626542
http://dx.doi.org/10.1159/000350288
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