Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study

Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Intere...

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Autores principales: Fujimura, Taku, Furudate, Sadanori, Ishibashi, Masaya, Kambayashi, Yumi, Tojo, Gen-ichi, Wakusawa, Chihiro, Mayama, Hiroshi, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: March, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617888/
https://www.ncbi.nlm.nih.gov/pubmed/23626544
http://dx.doi.org/10.1159/000350184
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author Fujimura, Taku
Furudate, Sadanori
Ishibashi, Masaya
Kambayashi, Yumi
Tojo, Gen-ichi
Wakusawa, Chihiro
Mayama, Hiroshi
Aiba, Setsuya
author_facet Fujimura, Taku
Furudate, Sadanori
Ishibashi, Masaya
Kambayashi, Yumi
Tojo, Gen-ichi
Wakusawa, Chihiro
Mayama, Hiroshi
Aiba, Setsuya
author_sort Fujimura, Taku
collection PubMed
description Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163(+) proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.
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spelling pubmed-36178882013-04-26 Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study Fujimura, Taku Furudate, Sadanori Ishibashi, Masaya Kambayashi, Yumi Tojo, Gen-ichi Wakusawa, Chihiro Mayama, Hiroshi Aiba, Setsuya Case Rep Dermatol Published online: March, 2013 Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163(+) proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC. S. Karger AG 2013-03-20 /pmc/articles/PMC3617888/ /pubmed/23626544 http://dx.doi.org/10.1159/000350184 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: March, 2013
Fujimura, Taku
Furudate, Sadanori
Ishibashi, Masaya
Kambayashi, Yumi
Tojo, Gen-ichi
Wakusawa, Chihiro
Mayama, Hiroshi
Aiba, Setsuya
Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study
title Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study
title_full Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study
title_fullStr Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study
title_full_unstemmed Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study
title_short Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study
title_sort successful treatment of plasmacytosis circumorificialis with topical tacrolimus: two case reports and an immunohistochemical study
topic Published online: March, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617888/
https://www.ncbi.nlm.nih.gov/pubmed/23626544
http://dx.doi.org/10.1159/000350184
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