Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study

We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages, together with Foxp3(+) regulatory T cells. Interestingly, MMP9, which was reported as one of the function...

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Autores principales: Furudate, Sadanori, Fujimura, Taku, Tojo, Gen-ichi, Haga, Takahiro, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: March, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617891/
https://www.ncbi.nlm.nih.gov/pubmed/23626541
http://dx.doi.org/10.1159/000350182
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author Furudate, Sadanori
Fujimura, Taku
Tojo, Gen-ichi
Haga, Takahiro
Aiba, Setsuya
author_facet Furudate, Sadanori
Fujimura, Taku
Tojo, Gen-ichi
Haga, Takahiro
Aiba, Setsuya
author_sort Furudate, Sadanori
collection PubMed
description We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages, together with Foxp3(+) regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was also detected in the CD163(+) M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.
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spelling pubmed-36178912013-04-26 Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study Furudate, Sadanori Fujimura, Taku Tojo, Gen-ichi Haga, Takahiro Aiba, Setsuya Case Rep Dermatol Published online: March, 2013 We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages, together with Foxp3(+) regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was also detected in the CD163(+) M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP. S. Karger AG 2013-03-09 /pmc/articles/PMC3617891/ /pubmed/23626541 http://dx.doi.org/10.1159/000350182 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: March, 2013
Furudate, Sadanori
Fujimura, Taku
Tojo, Gen-ichi
Haga, Takahiro
Aiba, Setsuya
Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_full Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_fullStr Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_full_unstemmed Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_short Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study
title_sort basal cell carcinoma arising from xeroderma pigmentosum: a case report and an immunohistochemical study
topic Published online: March, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617891/
https://www.ncbi.nlm.nih.gov/pubmed/23626541
http://dx.doi.org/10.1159/000350182
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