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Effective Treatment of Intestinal Behçet's Disease with Long-Term, Low-Dose Clarithromycin
A 51-year-old man was referred for body weight loss and lower right abdominal pain. Total colonoscopy revealed discrete and round ulceration at the ileocecal valve, and he was diagnosed with intestinal Behçet's disease (BD). By treatment with glucocorticoid, colchicine and salazosulfapyridine,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617967/ https://www.ncbi.nlm.nih.gov/pubmed/23626512 http://dx.doi.org/10.1159/000350320 |
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author | Hakozaki, Yukiya Mitani, Keiji Okada, Chizuko Terada, Hisato Kobari, Shinichi |
author_facet | Hakozaki, Yukiya Mitani, Keiji Okada, Chizuko Terada, Hisato Kobari, Shinichi |
author_sort | Hakozaki, Yukiya |
collection | PubMed |
description | A 51-year-old man was referred for body weight loss and lower right abdominal pain. Total colonoscopy revealed discrete and round ulceration at the ileocecal valve, and he was diagnosed with intestinal Behçet's disease (BD). By treatment with glucocorticoid, colchicine and salazosulfapyridine, the symptoms and ulceration were improved, but cessation of glucocorticoid resulted in relapse of ulceration at the terminal ileum. Long-term, low-dose treatment with clarithromycin (CAM) was implemented for chronic respiratory infections. Furthermore, we expected that this CAM treatment would also be effective in BD. During this long-term, low-dose treatment with CAM, discrete ulceration at the terminal ileum was never revealed by follow-up total colonoscopy once or twice per year for 7 years. No reports have described the effectiveness of this treatment in patients with intestinal BD; however, we confirm that long-term treatment with low-dose CAM might have clinical benefits for patients with intestinal BD. |
format | Online Article Text |
id | pubmed-3617967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-36179672013-04-26 Effective Treatment of Intestinal Behçet's Disease with Long-Term, Low-Dose Clarithromycin Hakozaki, Yukiya Mitani, Keiji Okada, Chizuko Terada, Hisato Kobari, Shinichi Case Rep Gastroenterol Published online: March, 2013 A 51-year-old man was referred for body weight loss and lower right abdominal pain. Total colonoscopy revealed discrete and round ulceration at the ileocecal valve, and he was diagnosed with intestinal Behçet's disease (BD). By treatment with glucocorticoid, colchicine and salazosulfapyridine, the symptoms and ulceration were improved, but cessation of glucocorticoid resulted in relapse of ulceration at the terminal ileum. Long-term, low-dose treatment with clarithromycin (CAM) was implemented for chronic respiratory infections. Furthermore, we expected that this CAM treatment would also be effective in BD. During this long-term, low-dose treatment with CAM, discrete ulceration at the terminal ileum was never revealed by follow-up total colonoscopy once or twice per year for 7 years. No reports have described the effectiveness of this treatment in patients with intestinal BD; however, we confirm that long-term treatment with low-dose CAM might have clinical benefits for patients with intestinal BD. S. Karger AG 2013-03-13 /pmc/articles/PMC3617967/ /pubmed/23626512 http://dx.doi.org/10.1159/000350320 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: March, 2013 Hakozaki, Yukiya Mitani, Keiji Okada, Chizuko Terada, Hisato Kobari, Shinichi Effective Treatment of Intestinal Behçet's Disease with Long-Term, Low-Dose Clarithromycin |
title | Effective Treatment of Intestinal Behçet's Disease with Long-Term, Low-Dose Clarithromycin |
title_full | Effective Treatment of Intestinal Behçet's Disease with Long-Term, Low-Dose Clarithromycin |
title_fullStr | Effective Treatment of Intestinal Behçet's Disease with Long-Term, Low-Dose Clarithromycin |
title_full_unstemmed | Effective Treatment of Intestinal Behçet's Disease with Long-Term, Low-Dose Clarithromycin |
title_short | Effective Treatment of Intestinal Behçet's Disease with Long-Term, Low-Dose Clarithromycin |
title_sort | effective treatment of intestinal behçet's disease with long-term, low-dose clarithromycin |
topic | Published online: March, 2013 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617967/ https://www.ncbi.nlm.nih.gov/pubmed/23626512 http://dx.doi.org/10.1159/000350320 |
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