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Comparing Diagnostic Accuracy of Cognitive Screening Instruments: A Weighted Comparison Approach

BACKGROUND/AIMS: There are many cognitive screening instruments available to clinicians when assessing patients' cognitive function, but the best way to compare the diagnostic utility of these tests is uncertain. One method is to undertake a weighted comparison which takes into account the diff...

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Autor principal: Larner, A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618026/
https://www.ncbi.nlm.nih.gov/pubmed/23569458
http://dx.doi.org/10.1159/000348623
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author Larner, A.J.
author_facet Larner, A.J.
author_sort Larner, A.J.
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description BACKGROUND/AIMS: There are many cognitive screening instruments available to clinicians when assessing patients' cognitive function, but the best way to compare the diagnostic utility of these tests is uncertain. One method is to undertake a weighted comparison which takes into account the difference in sensitivity and specificity of two tests, the relative clinical misclassification costs of true- and false-positive diagnosis, and also disease prevalence. METHODS: Data were examined from four pragmatic diagnostic accuracy studies from one clinic which compared the Mini-Mental State Examination (MMSE) with the Addenbrooke's Cognitive Examination-Revised (ACE-R), the Montreal Cognitive Assessment (MoCA), the Test Your Memory (TYM) test, and the Mini-Mental Parkinson (MMP), respectively. RESULTS: Weighted comparison calculations suggested a net benefit for ACE-R, MoCA, and MMP compared to MMSE, but a net loss for TYM test compared to MMSE. CONCLUSION: Routine incorporation of weighted comparison or other similar net benefit measures into diagnostic accuracy studies merits consideration to better inform clinicians of the relative value of cognitive screening instruments.
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spelling pubmed-36180262013-04-08 Comparing Diagnostic Accuracy of Cognitive Screening Instruments: A Weighted Comparison Approach Larner, A.J. Dement Geriatr Cogn Dis Extra Original Research Article BACKGROUND/AIMS: There are many cognitive screening instruments available to clinicians when assessing patients' cognitive function, but the best way to compare the diagnostic utility of these tests is uncertain. One method is to undertake a weighted comparison which takes into account the difference in sensitivity and specificity of two tests, the relative clinical misclassification costs of true- and false-positive diagnosis, and also disease prevalence. METHODS: Data were examined from four pragmatic diagnostic accuracy studies from one clinic which compared the Mini-Mental State Examination (MMSE) with the Addenbrooke's Cognitive Examination-Revised (ACE-R), the Montreal Cognitive Assessment (MoCA), the Test Your Memory (TYM) test, and the Mini-Mental Parkinson (MMP), respectively. RESULTS: Weighted comparison calculations suggested a net benefit for ACE-R, MoCA, and MMP compared to MMSE, but a net loss for TYM test compared to MMSE. CONCLUSION: Routine incorporation of weighted comparison or other similar net benefit measures into diagnostic accuracy studies merits consideration to better inform clinicians of the relative value of cognitive screening instruments. S. Karger AG 2013-03-01 /pmc/articles/PMC3618026/ /pubmed/23569458 http://dx.doi.org/10.1159/000348623 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Original Research Article
Larner, A.J.
Comparing Diagnostic Accuracy of Cognitive Screening Instruments: A Weighted Comparison Approach
title Comparing Diagnostic Accuracy of Cognitive Screening Instruments: A Weighted Comparison Approach
title_full Comparing Diagnostic Accuracy of Cognitive Screening Instruments: A Weighted Comparison Approach
title_fullStr Comparing Diagnostic Accuracy of Cognitive Screening Instruments: A Weighted Comparison Approach
title_full_unstemmed Comparing Diagnostic Accuracy of Cognitive Screening Instruments: A Weighted Comparison Approach
title_short Comparing Diagnostic Accuracy of Cognitive Screening Instruments: A Weighted Comparison Approach
title_sort comparing diagnostic accuracy of cognitive screening instruments: a weighted comparison approach
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618026/
https://www.ncbi.nlm.nih.gov/pubmed/23569458
http://dx.doi.org/10.1159/000348623
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